| Literature DB >> 32624337 |
Emily M Bertucci1, Benjamin B Parrott2.
Abstract
The genetic mechanisms contributing to lifespan variation remain unresolved. Based on recent conceptual advances in our understanding of epigenetic potential and the relocalization of chromatin modifiers (RCM), we hypothesize that increased CpG density is protective against age-related erosion of the epigenetic landscape and may explain interspecific variation in lifespan.Keywords: DNA methylation; epigenetic aging; epigenetic potential; lifespan
Mesh：
Year: 2020 PMID： 32624337 DOI： 10.1016/j.tig.2020.06.003
Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639