Shaul Z Kruger1, Susan E Bronskill2,3,4, Lianne Jeffs5,6,7, Marilyn Steinberg8, Andrew M Morris1,8, Chaim M Bell1,2,3,8,9. 1. Department of Medicine, University of Toronto, Toronto, Ontario, Canada. 2. ICES, Toronto, Ontario, Canada. 3. Institute of Health Policy, Management, and Evaluation (IHPME), University of Toronto, Toronto, Ontario, Canada. 4. Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada. 5. Department of Nursing, Sinai Health, Toronto, Ontario, Canada. 6. Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada. 7. Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario, Canada. 8. Antimicrobial Stewardship Program, Sinai Health/University Health Network, Toronto, Ontario, Canada. 9. Division of General Internal Medicine, Sinai Health, Toronto, Ontario, Canada.
Abstract
BACKGROUND: Antibiotic use in nursing homes is often inappropriate, in terms of overuse and misuse, and it can be linked to adverse events and antimicrobial resistance. Antimicrobial stewardship programs (ASPs) can optimize antibiotic use by minimizing unnecessary prescriptions, treatment cost, and the overall spread of antimicrobial resistance. Nursing home providers and residents are candidates for ASP implementation, yet guidelines for implementation are limited. OBJECTIVE: To support nursing home providers with the selection and adoption of ASP interventions. DESIGN AND SETTING: A multiphase modified Delphi method to assess 15 ASP interventions across criteria addressing scientific merit, feasibility, impact, accountability, and importance. This study included surveys supplemented with a 1-day consensus meeting. PARTICIPANTS: A 16-member multidisciplinary panel of experts and resident representatives. RESULTS: From highest to lowest, 6 interventions were prioritized by the panel: (1) guidelines for empiric prescribing, (2) audit and feedback, (3) communication tools, (4) short-course antibiotic therapy, (5) scheduled antibiotic reassessment, and (6) clinical decision support systems. Several interventions were not endorsed: antibiograms, educational interventions, formulary review, and automatic substitution. A lack of nursing home resources was noted, which could impede multifaceted interventions. CONCLUSIONS: Nursing home providers should consider 6 key interventions for ASPs. Such interventions may be feasible for nursing home settings and impactful for improving antibiotic use; however, scientific merit supporting each is variable. A multifaceted approach may be necessary for long-term improvement but difficult to implement.
BACKGROUND: Antibiotic use in nursing homes is often inappropriate, in terms of overuse and misuse, and it can be linked to adverse events and antimicrobial resistance. Antimicrobial stewardship programs (ASPs) can optimize antibiotic use by minimizing unnecessary prescriptions, treatment cost, and the overall spread of antimicrobial resistance. Nursing home providers and residents are candidates for ASP implementation, yet guidelines for implementation are limited. OBJECTIVE: To support nursing home providers with the selection and adoption of ASP interventions. DESIGN AND SETTING: A multiphase modified Delphi method to assess 15 ASP interventions across criteria addressing scientific merit, feasibility, impact, accountability, and importance. This study included surveys supplemented with a 1-day consensus meeting. PARTICIPANTS: A 16-member multidisciplinary panel of experts and resident representatives. RESULTS: From highest to lowest, 6 interventions were prioritized by the panel: (1) guidelines for empiric prescribing, (2) audit and feedback, (3) communication tools, (4) short-course antibiotic therapy, (5) scheduled antibiotic reassessment, and (6) clinical decision support systems. Several interventions were not endorsed: antibiograms, educational interventions, formulary review, and automatic substitution. A lack of nursing home resources was noted, which could impede multifaceted interventions. CONCLUSIONS: Nursing home providers should consider 6 key interventions for ASPs. Such interventions may be feasible for nursing home settings and impactful for improving antibiotic use; however, scientific merit supporting each is variable. A multifaceted approach may be necessary for long-term improvement but difficult to implement.