Literature DB >> 32623640

The Role of Arachidonic Acid Metabolism in Myocardial Ischemia-Reperfusion Injury.

Changjiang Zhang1,2,3, Meiling He4, Lihua Ni5, Ke He6, Ke Su6, Yinzhi Deng7, Yuanhong Li8, Hao Xia9,10,11.   

Abstract

Patients with myocardial ischemic diseases or who are undergoing one of various heart treatments, such as open heart surgery, coronary artery bypass grafting, percutaneous coronary artery intervention or drug thrombolysis, face myocardial ischemia-reperfusion injury (MIRI). However, no effective treatment is currently available for MIRI. To improve the prognosis of people with cardiovascular disease, it is important to research the mechanism of MIRI. Arachidonic acid (AA) is one of the focuses of current research. The various metabolic pathways of AA are closely related to the development of cardiovascular disease, and the roles of various metabolites in ischemia-reperfusion injury have gradually been confirmed. AA is mainly metabolized in the cyclooxygenase (COX) pathway, lipoxygenase (LOX) pathway, and cytochrome P450 monooxygenase (CYP) pathway. This paper summarizes the progress of research on these three major AA metabolic pathways with respect to MIRI.

Entities:  

Keywords:  Arachidonic acid; Cyclooxygenases; Cytochrome P450 monooxygenase; Lipoxygenases; Myocardial ischemia–reperfusion injury

Mesh：

Substances：

Year:  2020        PMID： 32623640     DOI： 10.1007/s12013-020-00928-z

Source DB:  PubMed          Journal:  Cell Biochem Biophys        ISSN： 1085-9195            Impact factor:   2.194


  8 in total

1.  Integrated Gut-Heart Axis and Network Pharmacology to Reveal the Mechanisms of the Huoxue Wentong Formula Against Myocardial Ischemia.

Authors:  Jianguo Lin; Qingqing Wang; Xin Hua; Jinlong Duan; Kuiwu Yao
Journal:  Evid Based Complement Alternat Med       Date:  2022-05-11       Impact factor: 2.650

2.  Metabolic Reprogramming of the Right Ventricle and Pulmonary Arteries in a Flow-Associated Pulmonary Arterial Hypertension Rat Model.

Authors:  Dongli Liu; Suyuan Qin; Danyan Su; Kai Wang; Yanyun Huang; Yuqin Huang; Yusheng Pang
Journal:  ACS Omega       Date:  2021-12-27

Review 3.  Inhibition of Myocardial Cell Apoptosis Is Important Mechanism for Ginsenoside in the Limitation of Myocardial Ischemia/Reperfusion Injury.

Authors:  Zhihan Chen; Jingping Wu; Sijing Li; Caijiao Liu; Yulan Ren
Journal:  Front Pharmacol       Date:  2022-03-01       Impact factor: 5.810

4.  CYP2E1 plays a suppressive role in hepatocellular carcinoma by regulating Wnt/Dvl2/β-catenin signaling.

Authors:  Lili Zhu; Xiaobei Yang; Jingyu Feng; Jian Mao; Qidong Zhang; Mengru He; Yang Mi; Yingwu Mei; Ge Jin; Haifeng Zhang
Journal:  J Transl Med       Date:  2022-05-04       Impact factor: 8.440

Review 5.  Focus on the role of mitochondria in NLRP3 inflammasome activation: A prospective target for the treatment of ischemic stroke (Review).

Authors:  Xiaolu Zhang; Wenyun Zeng; Yue Zhang; Qun Yu; Miao Zeng; Jiali Gan; Wenlan Zhang; Xijuan Jiang; Huhu Li
Journal:  Int J Mol Med       Date:  2022-04-08       Impact factor: 5.314

6.  Puerarin Induces Molecular Details of Ferroptosis-Associated Anti-Inflammatory on RAW264.7 Macrophages.

Authors:  Jinzi Zeng; Ning Zhao; Jiajia Yang; Weiyang Kuang; Xuewei Xia; Xiaodan Chen; Zhiyuan Liu; Riming Huang
Journal:  Metabolites       Date:  2022-07-15

Review 7.  Role of Oxidative Stress in Cardiac Dysfunction and Subcellular Defects Due to Ischemia-Reperfusion Injury.

Authors:  Naranjan S Dhalla; Anureet K Shah; Adriana Adameova; Monika Bartekova
Journal:  Biomedicines       Date:  2022-06-22

8.  DL-3-n-butylphthalide protects H9c2 cardiomyoblasts from ischemia/reperfusion injury by regulating HSP70 expression via PI3K/AKT pathway activation.

Authors:  Yunchen Yu; Yuying Zhu; Xiaotong Sun; Yongxing Li; Mingling Wang; Bin Dong; Xiaodong Sun; Wenming Hou
Journal:  Exp Ther Med       Date:  2021-07-15       Impact factor: 2.447
  8 in total

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