Literature DB >> 32622855

Flipping the Switch from Inflammation to Cell Death.

Hayley I Muendlein1, Alexander Poltorak2.   

Abstract

Multiple research groups have demonstrated that caspase-8 (CASP8)-mediated gasdermin D (GSDMD) cleavage drives pyroptotic cell death. Here, we discuss a novel role for the enzymatically inactive homolog of CASP8, the long isoform of cellular FLICE-like inhibitory protein (cFLIPL), in the regulation of this process. Specifically, cFLIP-deficiency provides a model in which to study the mechanisms regulating CASP8-mediated activation of cell death and inflammatory signaling.
Copyright © 2020 Elsevier Ltd. All rights reserved.

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Year:  2020        PMID： 32622855      PMCID： PMC7790434          DOI： 10.1016/j.it.2020.06.007

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  14 in total

1.  Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling.

Authors:  Nicholas Paquette; Joseph Conlon; Charles Sweet; Florentina Rus; Lindsay Wilson; Andrea Pereira; Charles V Rosadini; Nadege Goutagny; Alexander N R Weber; William S Lane; Scott A Shaffer; Stephanie Maniatis; Katherine A Fitzgerald; Lynda Stuart; Neal Silverman
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-16       Impact factor: 11.205

2.  Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.

Authors:  Dan Weng; Robyn Marty-Roix; Sandhya Ganesan; Megan K Proulx; Gregory I Vladimer; William J Kaiser; Edward S Mocarski; Kimberly Pouliot; Francis Ka-Ming Chan; Michelle A Kelliher; Phillip A Harris; John Bertin; Peter J Gough; Dmitry M Shayakhmetov; Jon D Goguen; Katherine A Fitzgerald; Neal Silverman; Egil Lien
Journal:  Proc Natl Acad Sci U S A       Date:  2014-05-05       Impact factor: 11.205

3.  Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly.

Authors:  Kaiwen W Chen; Benjamin Demarco; Rosalie Heilig; Kateryna Shkarina; Andreas Boettcher; Christopher J Farady; Pawel Pelczar; Petr Broz
Journal:  EMBO J       Date:  2019-03-22       Impact factor: 11.598

4.  A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4.

Authors:  Charles V Rosadini; Ivan Zanoni; Charlotte Odendall; Erin R Green; Michelle K Paczosa; Naomi H Philip; Igor E Brodsky; Joan Mecsas; Jonathan C Kagan
Journal:  Cell Host Microbe       Date:  2015-12-09       Impact factor: 21.023

5.  cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation.

Authors:  Hayley I Muendlein; David Jetton; Wilson M Connolly; Keith P Eidell; Zoie Magri; Irina Smirnova; Alexander Poltorak
Journal:  Science       Date:  2020-03-20       Impact factor: 47.728

6.  Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.

Authors:  Xing Liu; Zhibin Zhang; Jianbin Ruan; Youdong Pan; Venkat Giri Magupalli; Hao Wu; Judy Lieberman
Journal:  Nature       Date:  2016-07-07       Impact factor: 49.962

7.  Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection.

Authors:  Joseph Sarhan; Beiyun C Liu; Hayley I Muendlein; Peng Li; Rachael Nilson; Amy Y Tang; Anthony Rongvaux; Stephen C Bunnell; Feng Shao; Douglas R Green; Alexander Poltorak
Journal:  Proc Natl Acad Sci U S A       Date:  2018-10-31       Impact factor: 11.205

8.  Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.

Authors:  Pontus Orning; Dan Weng; Kristian Starheim; Dmitry Ratner; Zachary Best; Bettina Lee; Alexandria Brooks; Shiyu Xia; Hao Wu; Michelle A Kelliher; Scott B Berger; Peter J Gough; John Bertin; Megan M Proulx; Jon D Goguen; Nobuhiko Kayagaki; Katherine A Fitzgerald; Egil Lien
Journal:  Science       Date:  2018-10-25       Impact factor: 47.728

9.  Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.

Authors:  Wan-ting He; Haoqiang Wan; Lichen Hu; Pengda Chen; Xin Wang; Zhe Huang; Zhang-Hua Yang; Chuan-Qi Zhong; Jiahuai Han
Journal:  Cell Res       Date:  2015-11-27       Impact factor: 25.617

10.  Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity-independent pyroptosis, apoptosis, necroptosis, and inflammatory disease.

Authors:  R K Subbarao Malireddi; Prajwal Gurung; Sannula Kesavardhana; Parimal Samir; Amanda Burton; Harisankeerth Mummareddy; Peter Vogel; Stephane Pelletier; Sandeepta Burgula; Thirumala-Devi Kanneganti
Journal:  J Exp Med       Date:  2020-03-02       Impact factor: 14.307
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  3 in total

1.  [Inhibition of TAK1 aggravates airway inflammation by increasing RIPK1 activity and promoting macrophage death in a mouse model of toluene diisocyanate-induced asthma].

Authors:  S Yang; W Zhao; X Peng; Z Lan; J Huang; H Han; Y Chen; S Cai; H Zhao
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2022-02-20

2.  Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages.

Authors:  Xionghui Ding; Hiroto Kambara; Rongxia Guo; Apurva Kanneganti; Maikel Acosta-Zaldívar; Jiajia Li; Fei Liu; Ting Bei; Wanjun Qi; Xuemei Xie; Wenli Han; Ningning Liu; Cunling Zhang; Xiaoyu Zhang; Hongbo Yu; Li Zhao; Fengxia Ma; Julia R Köhler; Hongbo R Luo
Journal:  Nat Commun       Date:  2021-11-18       Impact factor: 14.919

3.  Tanshinone IIA prevents LPS-induced inflammatory responses in mice via inactivation of succinate dehydrogenase in macrophages.

Authors:  Qiu-Yan Liu; Yu Zhuang; Xian-Rui Song; Qun Niu; Qiu-Shuang Sun; Xiao-Nan Li; Ning Li; Bao-Lin Liu; Fang Huang; Zhi-Xia Qiu
Journal:  Acta Pharmacol Sin       Date:  2020-10-07       Impact factor: 7.169
  3 in total

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