Ghislain Labarthe1, Michael Dolores1, Mikael Verdalle-Cazes2, Cloé Charpentier3, Pauline Roullee1, Jean-Nicolas Dacher1, Guillaume Savoye3, Céline Savoye-Collet4. 1. Department of Radiology, Rouen University Hospital-Charles Nicolle, 1 rue de Germont, F-76031 Rouen cedex, France. 2. Department of Radiology, Rouen University Hospital-Charles Nicolle, 1 rue de Germont, F-76031 Rouen cedex, France; UNIROUEN, Quantif-LITIS EA 4108, Normandie Université, Rouen University Hospital, France. 3. UNIROUEN, INSERM U1073, Department of Gastroenterology, Normandie Université, Rouen University Hospital-Charles Nicolle, 1 rue de Germont, F-76031 Rouen cedex, France. 4. Department of Radiology, Rouen University Hospital-Charles Nicolle, 1 rue de Germont, F-76031 Rouen cedex, France; UNIROUEN, Quantif-LITIS EA 4108, Normandie Université, Rouen University Hospital, France. Electronic address: Celine.Savoye-Collet@chu-rouen.fr.
Abstract
BACKGROUND: Body composition, currently evaluated by computed tomography scan, is related to poor evolution and severity of Crohn's disease (CD). Few MRI studies have been performed, yet it is the most commonly used imaging modality for the surveillance of the disease. AIM: Evaluate the feasibility of MRI body composition measurement and compare the variation according to the activity of the disease. METHODS: A cohort of 132 consecutive patients was studied. The visceral adiposity index (VAI), subcutaneous adiposity index (SAI) and skeletal muscle index (SMI) were measured. Patients were divided into 2 groups according to disease activity. Sarcopenic status was defined according to the cut off value (SMI < 38.9 cm2/m2 in women and < 54.4 cm2/m2 in men). RESULTS: MRI measurements of body composition parameters were feasible and reproducible. After adjustment, sarcopenia was more common (2.07 [1.02; 4.27], p = 0.046), and the SMI (-4.90 [-9.36; -0.431], p = 0.032) was lower in active disease. The SAI was lower (-14.7 [-29.8; 0.258], p = 0.054) in active disease. The VAI tended to be higher with active disease (3.91 [-3.50; 11.9], p = 0.34), and the VAI/SAI+VAI ratio was higher (9.40 [4.72; 14.1], p<0.001). CONCLUSION: Assessment of body composition is feasible and reproducible in routine MR and parameters are related to disease activity.
BACKGROUND: Body composition, currently evaluated by computed tomography scan, is related to poor evolution and severity of Crohn's disease (CD). Few MRI studies have been performed, yet it is the most commonly used imaging modality for the surveillance of the disease. AIM: Evaluate the feasibility of MRI body composition measurement and compare the variation according to the activity of the disease. METHODS: A cohort of 132 consecutive patients was studied. The visceral adiposity index (VAI), subcutaneous adiposity index (SAI) and skeletal muscle index (SMI) were measured. Patients were divided into 2 groups according to disease activity. Sarcopenic status was defined according to the cut off value (SMI < 38.9 cm2/m2 in women and < 54.4 cm2/m2 in men). RESULTS: MRI measurements of body composition parameters were feasible and reproducible. After adjustment, sarcopenia was more common (2.07 [1.02; 4.27], p = 0.046), and the SMI (-4.90 [-9.36; -0.431], p = 0.032) was lower in active disease. The SAI was lower (-14.7 [-29.8; 0.258], p = 0.054) in active disease. The VAI tended to be higher with active disease (3.91 [-3.50; 11.9], p = 0.34), and the VAI/SAI+VAI ratio was higher (9.40 [4.72; 14.1], p<0.001). CONCLUSION: Assessment of body composition is feasible and reproducible in routine MR and parameters are related to disease activity.
Authors: Nik Sheng Ding; Daniel Tassone; Ibrahim Al Bakir; Kyle Wu; Alexander J Thompson; William R Connell; George Malietzis; Phillip Lung; Siddharth Singh; Chang-Ho Ryan Choi; Simon Gabe; John T Jenkins; Ailsa Hart Journal: J Crohns Colitis Date: 2022-09-08 Impact factor: 10.020
Authors: Sifan Liu; Xueli Ding; Giuseppe Maggiore; Andrea Pietrobattista; Sanjaya K Satapathy; Zibin Tian; Xue Jing Journal: Ann Transl Med Date: 2022-03