F A Cissé1, G M Osman2, B Legros3, C Depondt3, L J Hirsch4, A F Struck5, N Gaspard6. 1. Department of Neurology, Université Libre de Bruxelles - Hôpital Erasme, Bruxelles, Belgium; Department of Neurology, CHU de Conakry, Conakry, Guinea. 2. Department of Neurology, Henry Ford Hospital, Detroit, MI, USA; Department of Neurology and Comprehensive Epilepsy Center, Yale University, New Haven, CT, USA. 3. Department of Neurology, Université Libre de Bruxelles - Hôpital Erasme, Bruxelles, Belgium. 4. Department of Neurology and Comprehensive Epilepsy Center, Yale University, New Haven, CT, USA. 5. Department of Neurology, University of Wisconsin, Madison, WI, USA. 6. Department of Neurology, Université Libre de Bruxelles - Hôpital Erasme, Bruxelles, Belgium; Department of Neurology and Comprehensive Epilepsy Center, Yale University, New Haven, CT, USA. Electronic address: nicolas.gaspard@erasme.ulb.ac.be.
Abstract
OBJECTIVE: The clinical implementation of continuous electroencephalography (CEEG) monitoring in critically ill patients is hampered by the substantial burden of work that it entails for clinical neurophysiologists. Solutions that might reduce this burden, including by shortening the duration of EEG to be recorded, would help its widespread adoption. Our aim was to validate a recently described algorithm of time-dependent electro-clinical risk stratification for electrographic seizure (ESz) (TERSE) based on simple clinical and EEG features. METHODS: We retrospectively reviewed the medical records and EEG recordings of consecutive patients undergoing CEEG between October 1, 2015 and September, 30 2016 and assessed the sensitivity of TERSE for seizure detection, as well as the reduction in EEG time needed to be reviewed. RESULTS: In a cohort of 407 patients and compared to full CEEG review, the model allowed the detection of 95% of patients with ESz and 97% of those with electrographic status epilepticus. The amount of CEEG to be recorded to detect ESz was reduced by two-thirds, compared to the duration of CEEG taht was actually recorded. CONCLUSIONS: TERSE allowed accurate time-dependent ESz risk stratification with a high sensitivity for ESz detection, which could substantially reduce the amount of CEEG to be recorded and reviewed, if applied prospectively in clinical practice. SIGNIFICANCE: Time-dependent electro-clinical risk stratification, such as TERSE, could allow more efficient practice of CEEG and its more widespread adoption. Future studies should aim to improve risk stratification in the subgroup of patients with acute brain injury and absence of clinical seizures.
OBJECTIVE: The clinical implementation of continuous electroencephalography (CEEG) monitoring in critically illpatients is hampered by the substantial burden of work that it entails for clinical neurophysiologists. Solutions that might reduce this burden, including by shortening the duration of EEG to be recorded, would help its widespread adoption. Our aim was to validate a recently described algorithm of time-dependent electro-clinical risk stratification for electrographic seizure (ESz) (TERSE) based on simple clinical and EEG features. METHODS: We retrospectively reviewed the medical records and EEG recordings of consecutive patients undergoing CEEG between October 1, 2015 and September, 30 2016 and assessed the sensitivity of TERSE for seizure detection, as well as the reduction in EEG time needed to be reviewed. RESULTS: In a cohort of 407 patients and compared to full CEEG review, the model allowed the detection of 95% of patients with ESz and 97% of those with electrographic status epilepticus. The amount of CEEG to be recorded to detect ESz was reduced by two-thirds, compared to the duration of CEEG taht was actually recorded. CONCLUSIONS: TERSE allowed accurate time-dependent ESz risk stratification with a high sensitivity for ESz detection, which could substantially reduce the amount of CEEG to be recorded and reviewed, if applied prospectively in clinical practice. SIGNIFICANCE: Time-dependent electro-clinical risk stratification, such as TERSE, could allow more efficient practice of CEEG and its more widespread adoption. Future studies should aim to improve risk stratification in the subgroup of patients with acute brain injury and absence of clinical seizures.
Authors: Eric S Rosenthal; Jordan J Elm; James Ingles; Alexander J Rogers; Thomas E Terndrup; Maija Holsti; Danny G Thomas; Lynn Babcock; Pamela J Okada; Robert H Lipsky; Joseph B Miller; Robert W Hickey; Megan E Barra; Thomas P Bleck; James C Cloyd; Robert Silbergleit; Daniel H Lowenstein; Lisa D Coles; Jaideep Kapur; Shlomo Shinnar; James M Chamberlain Journal: Neurology Date: 2021-03-23 Impact factor: 9.910