Laveniya Satgunaseelan1, Benjamin M Allanson2, Rebecca Asher3, Rithvik Reddy4, Hubert T H Low5, Michael Veness6, N Gopal Iyer7, Robert I Smee8, Carsten E Palme9, Ruta Gupta10, Jonathan R Clark11. 1. Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Johns Hopkins Drive via Missenden Road, Camperdown, NSW 2050, Australia; Central Clinical School, University of Sydney, Parramatta Road, Camperdown, NSW 2050, Australia. Electronic address: Laveniya.Satgunaseelan@health.nsw.gov.au. 2. Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Johns Hopkins Drive via Missenden Road, Camperdown, NSW 2050, Australia. Electronic address: Benjamin.Allanson@health.nsw.gov.au. 3. NHMRC Clinical Trials Centre, University of Sydney Parramatta Road, Camperdown, NSW 2050, Australia. Electronic address: Rebecca.Asher@ctc.usyd.edu.au. 4. John Hunter Hospital, Lookout Rd, New Lambton Heights, NSW 2305, Australia. Electronic address: Rithvik.Reddy@health.nsw.gov.au. 5. Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Missenden Road, Camperdown, NSW 2050, Australia. 6. Department of Radiation Oncology, Westmead Hospital, Hawkesbury Road, Westmead, NSW 2145, Australia; Westmead Clinical School, University of Sydney, Hawkesbury Road, Westmead, NSW 2145, Australia. Electronic address: Michael.Veness@health.nsw.gov.au. 7. National Cancer Centre, Singapore, 11 Hospital Drive, Singapore 169610, Singapore. 8. Nelune Comprehensive Cancer Centre, 64-66 High St, Randwick, NSW 2031, Australia; Faculty of Medicine, University of New South Wales, 18 High Street, Kensington, NSW 2052, Australia. Electronic address: Robert.Smee1@health.nsw.gov.au. 9. Central Clinical School, University of Sydney, Parramatta Road, Camperdown, NSW 2050, Australia; Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Missenden Road, Camperdown, NSW 2050, Australia. Electronic address: Carsten.Palme@lh.org.au. 10. Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Johns Hopkins Drive via Missenden Road, Camperdown, NSW 2050, Australia; Central Clinical School, University of Sydney, Parramatta Road, Camperdown, NSW 2050, Australia; Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Missenden Road, Camperdown, NSW 2050, Australia. Electronic address: Ruta.Gupta@health.nsw.gov.au. 11. Central Clinical School, University of Sydney, Parramatta Road, Camperdown, NSW 2050, Australia; Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Missenden Road, Camperdown, NSW 2050, Australia. Electronic address: Jonathan.Clark@lh.org.au.
Abstract
PURPOSE: Increasing evidence is accumulating for an alarming rising incidence of oral tongue SCC in a younger cohort, particularly in developed countries. The aim of this study is to analyse the change in incidence of OSCC in patients under the age of 45 in developed nations in the Asia-Pacific region. PATIENTS AND METHODS: Population data was extracted from the Australian Cancer Incidence and Mortality 2017 database and National Registry of Diseases Office, Singapore to allow calculation of the incidence in the Australian and Singaporean populations. This was compared to multi-institutional data from four tertiary Australian institutions. The inclusion criteria were as follows: a) diagnosis of primary SCC of the mobile tongue; b) treatment with curative intent; c) complete histopathologic data; d) complete adjuvant treatment data; e) follow up data. RESULTS: Analysis of ACIM data demonstrated that there was a significant increase in the incidence of tongue SCC in those under the age of 45 in the Australian and Singaporean populations (p < 0.001). When analysed for gender, the incidence of tongue SCC increased at a significantly higher rate in females than males (p < 0.001). Similarly, in the multi-institutional analysis including 1814 patients, the number of females under the age of 45 with tongue SCC significantly increased over time (p < 0.001), with the proportion of smokers in this cohort decreasing over time. CONCLUSION: The incidence of tongue SCC is rising in young females in developed nations in the Asia Pacific region, in keeping with observed epidemiological trends worldwide.
PURPOSE: Increasing evidence is accumulating for an alarming rising incidence of oral tongue SCC in a younger cohort, particularly in developed countries. The aim of this study is to analyse the change in incidence of OSCC in patients under the age of 45 in developed nations in the Asia-Pacific region. PATIENTS AND METHODS: Population data was extracted from the Australian Cancer Incidence and Mortality 2017 database and National Registry of Diseases Office, Singapore to allow calculation of the incidence in the Australian and Singaporean populations. This was compared to multi-institutional data from four tertiary Australian institutions. The inclusion criteria were as follows: a) diagnosis of primary SCC of the mobile tongue; b) treatment with curative intent; c) complete histopathologic data; d) complete adjuvant treatment data; e) follow up data. RESULTS: Analysis of ACIM data demonstrated that there was a significant increase in the incidence of tongue SCC in those under the age of 45 in the Australian and Singaporean populations (p < 0.001). When analysed for gender, the incidence of tongue SCC increased at a significantly higher rate in females than males (p < 0.001). Similarly, in the multi-institutional analysis including 1814 patients, the number of females under the age of 45 with tongue SCC significantly increased over time (p < 0.001), with the proportion of smokers in this cohort decreasing over time. CONCLUSION: The incidence of tongue SCC is rising in young females in developed nations in the Asia Pacific region, in keeping with observed epidemiological trends worldwide.
Authors: Marta Tagliabue; Pietro Belloni; Rita De Berardinis; Sara Gandini; Francesco Chu; Stefano Zorzi; Caterina Fumagalli; Luigi Santoro; Susanna Chiocca; Mohssen Ansarin Journal: Cancer Med Date: 2021-03-24 Impact factor: 4.452
Authors: Jebrane Bouaoud; Paolo Bossi; Moshe Elkabets; Sandra Schmitz; Léon C van Kempen; Pierre Martinez; Sankar Jagadeeshan; Ingrid Breuskin; Gerwin J Puppels; Caroline Hoffmann; Keith D Hunter; Christian Simon; Jean-Pascal Machiels; Vincent Grégoire; Chloé Bertolus; Ruud H Brakenhoff; Senada Koljenović; Pierre Saintigny Journal: Cancers (Basel) Date: 2022-04-02 Impact factor: 6.639
Authors: Laveniya Satgunaseelan; Sean Porazinski; Dario Strbenac; Aji Istadi; Cali Willet; Tracy Chew; Rosemarie Sadsad; Carsten E Palme; Jenny H Lee; Michael Boyer; Jean Y H Yang; Jonathan R Clark; Marina Pajic; Ruta Gupta Journal: Front Oncol Date: 2021-11-29 Impact factor: 6.244