Andreas Clemmensen1, Adam E Hansen1, Pernille Holst2, Christina Schøier2, Sissel Bisgaard1, Helle H Johannesen1, Jan Henrik Ardenkjær-Larsen3, Annemarie T Kristensen2, Andreas Kjaer4. 1. Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Department of Biomedical Sciences, Rigshospitalet and University of Copenhagen Denmark, Copenhagen, Denmark. 2. Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark. 3. Department of Electrical Engineering, Technical University of Denmark, Kongens Lyngby, Denmark. 4. Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Department of Biomedical Sciences, Rigshospitalet and University of Copenhagen Denmark, Copenhagen, Denmark. akjaer@sund.ku.dk.
Abstract
PURPOSE: Cancer has a multitude of phenotypic expressions and identifying these are important for correct diagnosis and treatment selection. Clinical molecular imaging such as positron emission tomography can access several of these hallmarks of cancer non-invasively. Recently, hyperpolarized magnetic resonance spectroscopy with [1-13C] pyruvate has shown great potential to probe metabolic pathways. Here, we investigate simultaneous dual modality clinical molecular imaging of angiogenesis and deregulated energy metabolism in canine cancer patients. METHODS: Canine cancer patients (n = 11) underwent simultaneous [68Ga]Ga-NODAGA-E[(cRGDyK)]2 (RGD) PET and hyperpolarized [1-13C]pyruvate-MRSI (hyperPET). Standardized uptake values and [1-13C]lactate to total 13C ratio were quantified and compared generally and voxel-wise. RESULTS: Ten out of 11 patients showed clear tumor uptake of [68Ga]Ga-NODAGA-RGD at both 20 and 60 min after injection, with an average SUVmean of 1.36 ± 0.23 g/mL and 1.13 ± 0.21 g/mL, respectively. A similar pattern was seen for SUVmax values, which were 2.74 ± 0.41 g/mL and 2.37 ± 0.45 g/mL. The [1-13C]lactate generation followed patterns previously reported. We found no obvious pattern or consistent correlation between the two modalities. Voxel-wise tumor values of RGD uptake and lactate generation analysis revealed a tendency for each canine cancer patient to cluster in separated groups. CONCLUSION: We demonstrated combined imaging of [68Ga]Ga-NODAGA-RGD-PET for angiogenesis and hyperpolarized [1-13C]pyruvate-MRSI for probing energy metabolism. The results suggest that [68Ga]Ga-NODAGA-RGD-PET and [1-13C]pyruvate-MRSI may provide complementary information, indicating that hyperPET imaging of angiogenesis and energy metabolism is able to aid in cancer phenotyping, leading to improved therapy planning.
PURPOSE:Cancer has a multitude of phenotypic expressions and identifying these are important for correct diagnosis and treatment selection. Clinical molecular imaging such as positron emission tomography can access several of these hallmarks of cancer non-invasively. Recently, hyperpolarized magnetic resonance spectroscopy with [1-13C] pyruvate has shown great potential to probe metabolic pathways. Here, we investigate simultaneous dual modality clinical molecular imaging of angiogenesis and deregulated energy metabolism in caninecancerpatients. METHODS:Caninecancerpatients (n = 11) underwent simultaneous [68Ga]Ga-NODAGA-E[(cRGDyK)]2 (RGD) PET and hyperpolarized [1-13C]pyruvate-MRSI (hyperPET). Standardized uptake values and [1-13C]lactate to total 13C ratio were quantified and compared generally and voxel-wise. RESULTS: Ten out of 11 patients showed clear tumor uptake of [68Ga]Ga-NODAGA-RGD at both 20 and 60 min after injection, with an average SUVmean of 1.36 ± 0.23 g/mL and 1.13 ± 0.21 g/mL, respectively. A similar pattern was seen for SUVmax values, which were 2.74 ± 0.41 g/mL and 2.37 ± 0.45 g/mL. The [1-13C]lactate generation followed patterns previously reported. We found no obvious pattern or consistent correlation between the two modalities. Voxel-wise tumor values of RGD uptake and lactate generation analysis revealed a tendency for each caninecancerpatient to cluster in separated groups. CONCLUSION: We demonstrated combined imaging of [68Ga]Ga-NODAGA-RGD-PET for angiogenesis and hyperpolarized [1-13C]pyruvate-MRSI for probing energy metabolism. The results suggest that [68Ga]Ga-NODAGA-RGD-PET and [1-13C]pyruvate-MRSI may provide complementary information, indicating that hyperPET imaging of angiogenesis and energy metabolism is able to aid in cancer phenotyping, leading to improved therapy planning.
Authors: Adam E Hansen; Henrik Gutte; Pernille Holst; Helle H Johannesen; Sofie Rahbek; Andreas E Clemmensen; Majbritt M E Larsen; Christina Schøier; Jan Ardenkjaer-Larsen; Thomas L Klausen; Annemarie T Kristensen; Andreas Kjaer Journal: Eur J Radiol Date: 2018-02-25 Impact factor: 3.528
Authors: Ilwoo Park; Peder E Z Larson; Jeremy W Gordon; Lucas Carvajal; Hsin-Yu Chen; Robert Bok; Mark Van Criekinge; Marcus Ferrone; James B Slater; Duan Xu; John Kurhanewicz; Daniel B Vigneron; Susan Chang; Sarah J Nelson Journal: Magn Reson Med Date: 2018-01-10 Impact factor: 4.668
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Authors: Mark J Albers; Robert Bok; Albert P Chen; Charles H Cunningham; Matt L Zierhut; Vickie Yi Zhang; Susan J Kohler; James Tropp; Ralph E Hurd; Yi-Fen Yen; Sarah J Nelson; Daniel B Vigneron; John Kurhanewicz Journal: Cancer Res Date: 2008-10-15 Impact factor: 12.701
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