Literature DB >> 3261979

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase in transformed cells is a mitochondrial enzyme.

N R Mejia1, R E MacKenzie.   

Abstract

Transformed mammalian cells express a unique bifunctional NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase in addition to the usual NADP-dependent dehydrogenase-cyclohydrolase-synthetase. Subcellular fractionation of murine cell lines revealed that the NAD-dependent dehydrogenase activity is located predominantly in mitochondria, while the NADP-dependent trifunctional dehydrogenase appears to exist only in the cytosol of these cells. Western analysis using monospecific polyclonal antisera confirms the subcellular distribution of these two proteins.

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Year:  1988        PMID： 3261979     DOI： 10.1016/s0006-291x(88)81040-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  15 in total

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3.  Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations.

Authors:  D Schild; A J Brake; M C Kiefer; D Young; P J Barr
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

4.  Analysis of the promoter region of the gene encoding NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase.

Authors:  C Bélanger; K G Peri; R E MacKenzie
Journal:  Nucleic Acids Res       Date:  1991-08-25       Impact factor: 16.971

5.  Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major.

Authors:  Silvane M F Murta; Tim J Vickers; David A Scott; Stephen M Beverley
Journal:  Mol Microbiol       Date:  2009-01-16       Impact factor: 3.501

6.  Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos.

Authors:  Schuyler T Pike; Rashmi Rajendra; Karen Artzt; Dean R Appling
Journal:  J Biol Chem       Date:  2009-11-30       Impact factor: 5.157

7.  Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls.

Authors:  Priya Prasannan; Schuyler Pike; Kun Peng; Barry Shane; Dean R Appling
Journal:  J Biol Chem       Date:  2003-08-22       Impact factor: 5.157

8.  Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism.

Authors:  Amanda J MacFarlane; Cheryll A Perry; Hussein H Girnary; Dacao Gao; Robert H Allen; Sally P Stabler; Barry Shane; Patrick J Stover
Journal:  J Biol Chem       Date:  2008-11-25       Impact factor: 5.157

9.  Mitochondrial MTHFD2L is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase expressed in both adult and embryonic tissues.

Authors:  Minhye Shin; Joshua D Bryant; Jessica Momb; Dean R Appling
Journal:  J Biol Chem       Date:  2014-04-14       Impact factor: 5.157

10.  Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice.

Authors:  Jessica Momb; Jordan P Lewandowski; Joshua D Bryant; Rebecca Fitch; Deborah R Surman; Steven A Vokes; Dean R Appling
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-24       Impact factor: 11.205
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