| Literature DB >> 32618493 |
Xiwen Li1,2,3, Fangfang Zhang1,2,3, Jun Ma1,2,3, Xuelei Ruan1,2,3, Xiaobai Liu4,5,6, Jian Zheng4,5,6, Yunhui Liu4,5,6, Shuo Cao1,2,3, Shuyuan Shen1,2,3, Lianqi Shao1,2,3, Heng Cai4,5,6, Zhen Li4,5,6, Yixue Xue1,2,3.
Abstract
RNA-binding proteins (RBPs) are significantly dysregulated in glioma. In this study, we demonstrated the upregulation of Nuclear cap-binding subunit 3 (NCBP3) in glioma tissues and cells. Further, knockdown of NCBP3 inhibited the malignant progression of glioma. NCBP3 directly bound to small nucleolar RNA host gene 6 (SNHG6) and stabilized SNHG6 expression. In contrast, the gastrulation brain homeobox 2 (GBX2) transcription factor was downregulated in glioma tissues and cells. SNHG6 inhibited GBX2 transcription by mediating the H3K27me3 modification induced by polycomb repressive complex 2 (PRC2). Moreover, GBX2 decreased the promoter activities and downregulated the expression of the flotillin protein family 1 (FLOT1) oncogene. In conclusion, NCBP3/SNHG6 inhibits GBX2 transcription in a PRC2-dependent manner to facilitate the malignant progression of gliomas.Entities:
Keywords: H3K27me3; RNA-binding proteins; glioma; long non-coding RNA
Year: 2020 PMID： 32618493 PMCID： PMC7833770 DOI： 10.1080/15476286.2020.1790140
Source DB: PubMed Journal: RNA Biol ISSN： 1547-6286 Impact factor: 4.652