| Literature DB >> 32617778 |
Emily C Williams1,2, Kathleen A McGinnis3, Anna D Rubinsky4,5, Theresa E Matson4,6,7, Jennifer F Bobb7, Gwen T Lapham4,7, E Jennifer Edelman8, Derek D Satre9,10, Sheryl L Catz11, Julie E Richards6,7, Kendall J Bryant12, Brandon D L Marshall13, Kevin L Kraemer14,15, Stephen Crystal16, Adam J Gordon17,18, Melissa Skanderson3, David A Fiellin3,8, Amy C Justice3,8, Katharine A Bradley4,6,7,19,20.
Abstract
Alcohol use increases non-adherence to antiretroviral therapy (ART) among persons living with HIV (PLWH). Dynamic longitudinal associations are understudied. Veterans Aging Cohort Study (VACS) data 2/1/2008-7/31/16 were used to fit linear regression models estimating changes in adherence (% days with ART medication fill) associated with changes in alcohol use based on annual clinically-ascertained AUDIT-C screening scores (range - 12 to + 12, 0 = no change) adjusting for demographics and initial adherence. Among 21,275 PLWH (67,330 observations), most reported no (48%) or low-level (39%) alcohol use initially, with no (55%) or small (39% ≤ 3 points) annual change. Mean initial adherence was 86% (SD 21%), mean annual change was - 3.1% (SD 21%). An inverted V-shaped association was observed: both increases and decreases in AUDIT-C were associated with greater adherence decreases relative to stable scores [p < 0.001, F (4, 21,274)]. PLWH with dynamic alcohol use (potentially indicative of alcohol use disorder) should be considered for adherence interventions.Entities:
Keywords: ART; Adherence; Alcohol use; Antiretroviral therapy; HIV
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Year: 2021 PMID： 32617778 PMCID： PMC7775874 DOI： 10.1007/s10461-020-02950-x
Source DB: PubMed Journal: AIDS Behav ISSN： 1090-7165