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Literature DB >> 32615822

Exosomes derived from synovial fibroblasts under hypoxia aggravate rheumatoid arthritis by regulating Treg/Th17 balance.

Yanjie Ding^1,2, Laifang Wang², Huiqiang Wu², Qing Zhao², Shufang Wu¹.

Abstract

IMPACT STATEMENT: A comparative study of osteoarthritis (OA) and RA mice was implemented to suggest that miR-424 expression was increased in RA, and exosome-miR-424 derived from synovial fibroblasts (SFs-exo) could significantly induce T cells differentiation in which Th17 cells increased and Treg cells decreased via targeting FOXP3. And thus, miR-424 may be a potential therapeutic target for RA.

Entities: Chemical Disease Gene Species

Keywords: Hypoxia; Th17/Treg cells; exosome; rheumatoid arthritis

Mesh：

Substances：

Year: 2020 PMID： 32615822 PMCID： PMC7437376 DOI： 10.1177/1535370220934736

Source DB: PubMed Journal: Exp Biol Med (Maywood) ISSN： 1535-3699

59 in total

1. Absorption, distribution, metabolism, and excretion of a respirable antisense oligonucleotide for asthma.

Authors: S Ali; S A Leonard; C A Kukoly; W J Metzger; W R Wooles; J F McGinty; M Tanaka; A Sandrasagra; J W Nyce
Journal: Am J Respir Crit Care Med Date: 2001-03 Impact factor: 21.405

Review 2. IL-17 and Th17 Cells.

Authors: Thomas Korn; Estelle Bettelli; Mohamed Oukka; Vijay K Kuchroo
Journal: Annu Rev Immunol Date: 2009 Impact factor: 28.527

Review 3. Biogenesis and secretion of exosomes.

Authors: Joanna Kowal; Mercedes Tkach; Clotilde Théry
Journal: Curr Opin Cell Biol Date: 2014-06-22 Impact factor: 8.382

4. The Changes of Th17/Treg and Related Cytokines: IL-17, IL-23, IL-10, and TGF-β in Respiratory Syncytial Virus Bronchiolitis Rat Model.

Authors: Meng Gao; Liang-Xiao Liu; Fu-Ling Wu; Xuejing Zhang; Ying-Ying Li; Tao Shi; De-Zhi Li; Ting-Ting Han
Journal: Iran J Allergy Asthma Immunol Date: 2017-10 Impact factor: 1.464

Review 5. Homeostatic control of regulatory T cell diversity.

Authors: Adrian Liston; Daniel H D Gray
Journal: Nat Rev Immunol Date: 2014-01-31 Impact factor: 53.106

6. MicroRNA and exosome: Key players in rheumatoid arthritis.

Authors: Zahra Zakeri; Arash Salmaninejad; Nayyerehalsadat Hosseini; Yas Shahbakhsh; Elyas Fadaee; Mohammad Karim Shahrzad; Sara Fadaei
Journal: J Cell Biochem Date: 2019-03-01 Impact factor: 4.429

7. Expression of microRNA-146 in rheumatoid arthritis synovial tissue.

Authors: Tomoyuki Nakasa; Shigeru Miyaki; Atsuko Okubo; Megumi Hashimoto; Keiichiro Nishida; Mitsuo Ochi; Hiroshi Asahara
Journal: Arthritis Rheum Date: 2008-05

8. Inhibition of RELM-β prevents hypoxia-induced overproliferation of human pulmonary artery smooth muscle cells by reversing PLC-mediated KCNK3 decline.

Authors: Linlin Han; Nannan Song; Xiaomin Hu; Afang Zhu; Xin Wei; Jinmin Liu; Shiying Yuan; Weike Mao; Xiangdong Chen
Journal: Life Sci Date: 2020-02-08 Impact factor: 5.037

Review 9. Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis.

Authors: Ursula Fearon; Mary Canavan; Monika Biniecka; Douglas J Veale
Journal: Nat Rev Rheumatol Date: 2016-05-26 Impact factor: 20.543

10. Double-stranded DNA in exosomes: a novel biomarker in cancer detection.

Authors: Basant Kumar Thakur; Haiying Zhang; Annette Becker; Irina Matei; Yujie Huang; Bruno Costa-Silva; Yan Zheng; Ayuko Hoshino; Helene Brazier; Jenny Xiang; Caitlin Williams; Ruth Rodriguez-Barrueco; Jose M Silva; Weijia Zhang; Stephen Hearn; Olivier Elemento; Navid Paknejad; Katia Manova-Todorova; Karl Welte; Jacqueline Bromberg; Héctor Peinado; David Lyden
Journal: Cell Res Date: 2014-04-08 Impact factor: 25.617

9 in total

Exosomes derived from synovial fibroblasts under hypoxia aggravate rheumatoid arthritis by regulating Treg/Th17 balance.

1. Absorption, distribution, metabolism, and excretion of a respirable antisense oligonucleotide for asthma.

Review 2. IL-17 and Th17 Cells.

Review 3. Biogenesis and secretion of exosomes.

4. The Changes of Th17/Treg and Related Cytokines: IL-17, IL-23, IL-10, and TGF-β in Respiratory Syncytial Virus Bronchiolitis Rat Model.

Review 5. Homeostatic control of regulatory T cell diversity.

6. MicroRNA and exosome: Key players in rheumatoid arthritis.

7. Expression of microRNA-146 in rheumatoid arthritis synovial tissue.

8. Inhibition of RELM-β prevents hypoxia-induced overproliferation of human pulmonary artery smooth muscle cells by reversing PLC-mediated KCNK3 decline.

Review 9. Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis.

10. Double-stranded DNA in exosomes: a novel biomarker in cancer detection.

1. CLP1 is a Prognosis-Related Biomarker and Correlates With Immune Infiltrates in Rheumatoid Arthritis.

Review 2. The Role of Extracellular Vesicles in the Pathogenesis, Diagnosis, and Treatment of Osteoarthritis.

Review 3. Function and Role of Regulatory T Cells in Rheumatoid Arthritis.

4. Wu-Teng-Gao External Treatment Improves Th17/Treg Balance in Rheumatoid Arthritis.

Review 5. Role of Exosomal Non-Coding RNAs in Bone-Related Diseases.

Review 6. Research Progress in the Application of Exosomes in Immunotherapy.

7. Extracellular Vesicles From Kidney Allografts Express miR-218-5p and Alter Th17/Treg Ratios.

Review 8. Hypoxia Induced Changes of Exosome Cargo and Subsequent Biological Effects.

Review 9. Knowledge Mapping of Exosomes in Autoimmune Diseases: A Bibliometric Analysis (2002-2021).