Joy E Olsen1, Jeanie L Y Cheong2, Abbey L Eeles2, Tara L FitzGerald2, Kate L Cameron3, Reem A Albesher4, Peter J Anderson5, Lex W Doyle2, Alicia J Spittle2. 1. University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia; Murdoch Children's Research Institute, 50 Flemington Road, Parkville, Victoria 3052, Australia; The Royal Women's Hospital, 20 Flemington Road, Parkville, Victoria 3052, Australia. Electronic address: joy.olsen@thewomens.org.au. 2. University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia; Murdoch Children's Research Institute, 50 Flemington Road, Parkville, Victoria 3052, Australia; The Royal Women's Hospital, 20 Flemington Road, Parkville, Victoria 3052, Australia. 3. University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia; Murdoch Children's Research Institute, 50 Flemington Road, Parkville, Victoria 3052, Australia. 4. University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia; Murdoch Children's Research Institute, 50 Flemington Road, Parkville, Victoria 3052, Australia; Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. 5. University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia; Murdoch Children's Research Institute, 50 Flemington Road, Parkville, Victoria 3052, Australia; Monash University, Wellington Road, Clayton, Victoria 3168, Australia.
Abstract
BACKGROUND: Prechtl's general movements assessment (GMA) post-term has high predictive validity for cerebral palsy, but less is known about whether earlier GMA, including before term, are associated with other developmental problems. AIMS: To examine the relationships between GMA prior to term and at term-equivalent, with developmental outcomes at 4.5-5 years' corrected age. STUDY DESIGN: Prospective cohort study. SUBJECTS: 122 very preterm infants born <30 weeks' gestation and 91 healthy term controls. OUTCOME MEASURES: GMA (categorised as 'normal' or 'abnormal') were assessed at <32, 32-33 and 34-36 weeks' postmenstrual age for the preterm infants, and at term-equivalent for both groups. Children were assessed at 4.5-5 years' corrected age using the Movement Assessment Battery for Children-2nd edition (MABC-2), Pediatric Evaluation of Disability Inventory-Computer Adaptive Test (PEDI-CAT), Pediatric Quality of Life Inventory (PedsQL), Little Developmental Coordination Disorder Questionnaire (Little DCD-Q) and Wechsler Preschool and Primary Scale of Intelligence-IV (WPPSI-IV). RESULTS: Prior to term, abnormal GMA at the first two timepoints were associated with lower scores on the Little DCD-Q, and abnormal GMA at the second and third timepoints with lower quality of life scores and PEDI-CAT mobility domain scores. Abnormal GMA at term-equivalent were associated with lower MABC-2, mobility and quality of life scores for preterm infants, and worse social/cognitive domain scores for both groups. CONCLUSIONS: Abnormal GMA prior to term and at term-equivalent are associated with worse motor, functional and cognitive outcomes at 4.5-5 years' corrected age, and may be useful to identify infants for developmental surveillance/early intervention.
BACKGROUND: Prechtl's general movements assessment (GMA) post-term has high predictive validity for cerebral palsy, but less is known about whether earlier GMA, including before term, are associated with other developmental problems. AIMS: To examine the relationships between GMA prior to term and at term-equivalent, with developmental outcomes at 4.5-5 years' corrected age. STUDY DESIGN: Prospective cohort study. SUBJECTS: 122 very preterm infants born <30 weeks' gestation and 91 healthy term controls. OUTCOME MEASURES: GMA (categorised as 'normal' or 'abnormal') were assessed at <32, 32-33 and 34-36 weeks' postmenstrual age for the preterm infants, and at term-equivalent for both groups. Children were assessed at 4.5-5 years' corrected age using the Movement Assessment Battery for Children-2nd edition (MABC-2), Pediatric Evaluation of Disability Inventory-Computer Adaptive Test (PEDI-CAT), Pediatric Quality of Life Inventory (PedsQL), Little Developmental Coordination Disorder Questionnaire (Little DCD-Q) and Wechsler Preschool and Primary Scale of Intelligence-IV (WPPSI-IV). RESULTS: Prior to term, abnormal GMA at the first two timepoints were associated with lower scores on the Little DCD-Q, and abnormal GMA at the second and third timepoints with lower quality of life scores and PEDI-CAT mobility domain scores. Abnormal GMA at term-equivalent were associated with lower MABC-2, mobility and quality of life scores for preterm infants, and worse social/cognitive domain scores for both groups. CONCLUSIONS: Abnormal GMA prior to term and at term-equivalent are associated with worse motor, functional and cognitive outcomes at 4.5-5 years' corrected age, and may be useful to identify infants for developmental surveillance/early intervention.
Authors: Sung Wook Kim; Lazaros Andronis; Anna-Veera Seppänen; Adrien M Aubert; Henrique Barros; Elizabeth S Draper; Mariane Sentenac; Jennifer Zeitlin; Stavros Petrou Journal: Qual Life Res Date: 2022-08-17 Impact factor: 3.440
Authors: Carly R Luke; Katherine Benfer; Leeann Mick-Ramsamy; Robert S Ware; Natasha Reid; Arend F Bos; Margot Bosanquet; Roslyn N Boyd Journal: BMJ Open Date: 2022-01-07 Impact factor: 2.692