| Literature DB >> 32615046 |
Dinu Stanescu-Segall1, Thomas Sales de Gauzy1, Rhianon Reynolds2, Livia Faes3, Dominika Pohlmann4, Kaivon Pakzad-Vaezi5, Daniel Ting6, David Saadoun7, Jayakrishna Ambati8, Anat Loewenstein9, Bahram Bodaghi1, Marc D de Smet10, Sara Touhami1.
Abstract
INTRODUCTION: Routine medical and ophthalmic care is being drastically curtailed in the context of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Uveitis patients require particular attention because of their theoretical risk of viral infection, in the context of therapeutic immunosuppression. AREAS COVERED: This collaborative work proposes practical management and follow-up criteria for uveitis patients in the context of the ongoing SARS-CoV-2 pandemic. EXPERT OPINION: Management should proceed as usual when access to health care possible in patients who do not belong to a group at high risk of severe SARS-CoV-2 infection, and in uncontrolled uveitis cases. In case of reduced access to eye clinics or high risk of SARS-CoV-2 infection, patients' management should be stratified based on their clinical presentation. In non-severe uveitis cases, the use of systemic steroids should be avoided, and local steroids preferred whenever possible. In uncontrolled situations where there is real risk of permanent visual loss, high-dose intravenous steroids and/or systemic immunosuppressants and/or biotherapies can be administered depending on the severity of eye disease. Immunosuppressive therapy should not be withheld, unless the patient develops SARS-CoV2 infection.Entities:
Keywords: SARS-CoV-2; Uveitis; biologics; coronavirus; corticosteroid; immunosuppression; immunosuppressive therapy; intravitreous injection; management
Mesh:
Year: 2020 PMID: 32615046 DOI: 10.1080/1744666X.2020.1791086
Source DB: PubMed Journal: Expert Rev Clin Immunol ISSN: 1744-666X Impact factor: 4.473