Ying Sun1, Wei Wang1, Yue-Ru Jiao1, Jian Ren2, Lei Gao3, Yang Li3, Ping Hu3, Tian-Ying Ren3, Qian-Feng Han1, Chen Chen4, Heng-Chen Yao1. 1. Department of Cardiology, Liaocheng People's Hospital, Cheeloo college of Medicine, Shandong University & Clinical School of Shandong First Medical University, Liaocheng, Shandong Province, 252000, China. 2. Department of Cardiology, Liaocheng Dongchangfu People's Hospital, The second affiliated Hospital of Liaocheng University, Liaocheng, 252000, China. 3. Zhong Yuan Academy of Biological Medicine, Liaocheng People's Hospital, Shandong University, Liaocheng, Shandong Province, 252000, China. 4. Department of Urology, Liaocheng People's Hospital, Cheeloo college of Medicine, Shandong University & Clinical School of Shandong First Medical University, Liaocheng, Shandong Province, 252000, China.
Abstract
Aim: This study aimed to explore the prognostic value of leukocyte telomere length (LTL) in patients with coronary artery disease (CAD). Materials & methods: We enrolled 366 CAD patients and 76 healthy subjects in this study. LTL was measured. All subjects were followed up for 6 months for further analysis regarding major adverse cardiac events (MACEs). Results: CAD patients had a significantly shortened LTL compared with healthy subjects (p < 0.05). The area under the curve for LTL prediction of MACEs was 0.769 (p < 0.001), with a shorter LTL being an independent predictor of MACEs (Cox proportional hazards regression, hazard ratio: 2.866; p < 0.001). Conclusion: LTL could be considered as an independent predictor of short-term MACEs in CAD.
Aim: This study aimed to explore the prognostic value of leukocyte telomere length (LTL) in patients with coronary artery disease (CAD). Materials & methods: We enrolled 366 CAD patients and 76 healthy subjects in this study. LTL was measured. All subjects were followed up for 6 months for further analysis regarding major adverse cardiac events (MACEs). Results: CAD patients had a significantly shortened LTL compared with healthy subjects (p < 0.05). The area under the curve for LTL prediction of MACEs was 0.769 (p < 0.001), with a shorter LTL being an independent predictor of MACEs (Cox proportional hazards regression, hazard ratio: 2.866; p < 0.001). Conclusion: LTL could be considered as an independent predictor of short-term MACEs in CAD.
Authors: Olga V Zimnitskaya; Marina M Petrova; Natalia V Lareva; Marina S Cherniaeva; Mustafa Al-Zamil; Anastasia E Ivanova; Natalia A Shnayder Journal: Genes (Basel) Date: 2022-07-12 Impact factor: 4.141