Literature DB >> 3261272

Linkage between the variegate porphyria (VP) and the alpha-1-antitrypsin (PI) genes on human chromosome 14.

S Bissbort1, H W Hitzeroth, D P du Wentzel, C W Van den Berg, H Senff, T F Wienker, K Bender.   

Abstract

From family studies close linkage between the gene locus for variegate porphyria (VP) and the alpha-1-antitrypsin (PI) gene became evident. The maximal lod score from male meioses was 4.33 at theta = 0.04 and from both sexes combined 3.56 at theta = 0.12. Three pedigrees were triple informative regarding loci VP, PI, and IGHC (immunoglobulin heavy chain cluster, Gm polymorphism). In two of the respective meioses recombinations were observed, and in both cases the co-segregating VP and PI alleles were separated from the Gm haplotypes. These findings argue in favour of gene order either VP:PI:IGHC or PI:VP:IGHC.

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Year:  1988        PMID： 3261272     DOI： 10.1007/bf00366255

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  8 in total

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Journal:  Nature       Date:  1982-06-03       Impact factor: 49.962

6.  Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing gamma, epsilon and alpha genes.

Authors:  J G Flanagan; T H Rabbitts
Journal:  Nature       Date:  1982-12-23       Impact factor: 49.962

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Authors:  D A Brenner; J R Bloomer
Journal:  N Engl J Med       Date:  1980-04-03       Impact factor: 91.245

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Authors:  M P Lefranc; G Lefranc; T H Rabbitts
Journal:  Nature       Date:  1982-12-23       Impact factor: 49.962
  8 in total
  8 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
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Authors:  T Jenkins
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Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

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Authors:  L Warnich; P N Meissner; R J Hift; J H Louw; C J van Heerden; A E Retief
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Authors:  G H Elder
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6.  The human corticosteroid binding globulin gene is located on chromosome 14q31-q32.1 near two other serine protease inhibitor genes.

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Journal:  Hum Genet       Date:  1990-11       Impact factor: 4.132

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Authors:  D Kamnasaran; D W Cox
Journal:  J Med Genet       Date:  2002-02       Impact factor: 6.318

8.  Evidence for involvement of a second genetic locus on chromosome 11q in porphyrin metabolism.

Authors:  B Norton; W G Lanyon; M R Moore; M Porteous; G R Youngs; J M Connor
Journal:  Hum Genet       Date:  1993-07       Impact factor: 4.132
  8 in total

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