| Literature DB >> 3260938 |
S Okusawa1, K B Yancey, J W van der Meer, S Endres, G Lonnemann, K Hefter, M M Frank, J F Burke, C A Dinarello, J A Gelfand.
Abstract
We have demonstrated that purified C5a is a potent stimulus to human PBMC secretion of TNF-alpha, IL-1 beta, and IL-1 alpha, which proceeds in a dose-dependent fashion. At a given concentration of C5a, TNF-alpha and IL-1 beta secretion did not differ significantly; both were secreted in significantly greater quantity than IL-1 alpha. Clinical conditions such as Gram-positive and Gram-negative bacterial infections, trauma, and immune complex diseases activate complement. Through the mediation of TNF and IL-1 secreted in response to C5a, these diverse disorders can share common features of fever, coagulopathy, acute phase protein production, and disordered metabolism.Entities:
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Year: 1988 PMID： 3260938 PMCID： PMC2188974 DOI： 10.1084/jem.168.1.443
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307