Literature DB >> 3260867

Morphine-induced immunomodulation is not related to serum morphine concentrations.

H U Bryant1, B C Yoburn, C E Inturrisi, E W Bernton, J W Holaday.   

Abstract

Morphine pellets produced atrophy of the spleen and thymus and affected mitogen-induced lymphocyte proliferation in mice as characterized by marked suppression of concanavalin A-induced blastogenesis at 48 h, and mild stimulation at 120 h. Morphine blood levels in these animals indicated that changes in the immunomodulatory effects of morphine over time were not related to dramatic shifts in circulating morphine. Enclosure of the pellet in nylon mesh did not alter blood levels or morphine-induced immunomodulation.

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Year:  1988        PMID： 3260867     DOI： 10.1016/0014-2999(88)90057-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  16 in total

1.  Increased sensitivity to Salmonella enterica serovar Typhimurium infection in mice undergoing withdrawal from morphine is associated with suppression of interleukin-12.

Authors:  Pu Feng; Qiana M Wilson; Joseph J Meissler; Martin W Adler; Toby K Eisenstein
Journal:  Infect Immun       Date:  2005-12       Impact factor: 3.441

2.  Morphine, but not trauma, sensitizes to systemic Acinetobacter baumannii infection.

Authors:  Jessica M Breslow; M Alexandra Monroy; John M Daly; Joseph J Meissler; John Gaughan; Martin W Adler; Toby K Eisenstein
Journal:  J Neuroimmune Pharmacol       Date:  2011-08-09       Impact factor: 4.147

Review 3.  Comparison and analysis of the animal models used to study the effect of morphine on tumour growth and metastasis.

Authors:  B Afsharimani; C W Doornebal; P J Cabot; M W Hollmann; M-O Parat
Journal:  Br J Pharmacol       Date:  2014-07-01       Impact factor: 8.739

4.  Potentiating effect of morphine on oral Salmonella enterica serovar Typhimurium infection is μ-opioid receptor-dependent.

Authors:  Jessica M Breslow; Pu Feng; Joseph J Meissler; John E Pintar; John Gaughan; Martin W Adler; Toby K Eisenstein
Journal:  Microb Pathog       Date:  2010-08-03       Impact factor: 3.738

5.  Depletion and recovery of lymphoid subsets following morphine administration.

Authors:  E Y Zhang; J Xiong; B L Parker; A Y Chen; P E Fields; X Ma; J Qiu; T M Yankee
Journal:  Br J Pharmacol       Date:  2011-12       Impact factor: 8.739

6.  Morphine withdrawal lowers host defense to enteric bacteria: spontaneous sepsis and increased sensitivity to oral Salmonella enterica serovar Typhimurium infection.

Authors:  Pu Feng; Allan L Truant; Joseph J Meissler; John P Gaughan; Martin W Adler; Toby K Eisenstein
Journal:  Infect Immun       Date:  2006-09       Impact factor: 3.441

7.  Opioid use potentiates the virulence of hospital-acquired infection, increases systemic bacterial dissemination and exacerbates gut dysbiosis in a murine model of Citrobacter rodentium infection.

Authors:  Fuyuan Wang; Jingjing Meng; Li Zhang; Sabita Roy
Journal:  Gut Microbes       Date:  2019-08-05

Review 8.  Intensive Care Unit-acquired infection as a side effect of sedation.

Authors:  Saad Nseir; Demosthenes Makris; Daniel Mathieu; Alain Durocher; Charles-Hugo Marquette
Journal:  Crit Care       Date:  2010-03-15       Impact factor: 9.097

9.  Anti-CD40 antibody and toll-like receptor 3 ligand restore dendritic cell-mediated anti-tumor immunity suppressed by morphine.

Authors:  Ming-Cheng Chang; Yu-Li Chen; Ying-Cheng Chiang; Ya-Jung Cheng; Yu-Wei Jen; Chi-An Chen; Wen-Fang Cheng; Wei-Zen Sun
Journal:  Am J Cancer Res       Date:  2016-01-15       Impact factor: 6.166

10.  Chronic β1-adrenoceptor blockade impairs ischaemic tolerance and preconditioning in murine myocardium.

Authors:  Louise E See Hoe; Jan M Schilling; Anna R Busija; Kristofer J Haushalter; Victoria Ozberk; Malik M Keshwani; David M Roth; Eugene Du Toit; John P Headrick; Hemal H Patel; Jason N Peart
Journal:  Eur J Pharmacol       Date:  2016-06-30       Impact factor: 4.432
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