Nicolae Bacalbasa1,2,3, Dragos Cretoiu4,5, Ioana Halmaciu6, Camelia Diaconu4,7, Laura Iliescu4,8, Simona Dima3, Adrian Neacsu4,9, Cristian Balalau4,10, Ovidiu Gabriel Bratu4,11, Irina Balescu12. 1. "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania nicolae_bacalbasa@yahoo.ro. 2. Department of Obstetrics and Gynecology, "I. Cantacuzino" Clinical Hospital, Bucharest, Romania. 3. Department of Visceral Surgery, Center of Excellence in Translational Medicine "Fundeni" Clinical Institute, Bucharest, Romania. 4. "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. 5. "Alessandrescu-Rusescu" National Institute of Mother and Child Health, Fetal Medicine Excellence Research Center, Bucharest, Romania. 6. Department of Anatomy, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology, Târgu Mureş, Romania. 7. Department of Internal Medicine, University Emergency Hospital Bucharest, Bucharest, Romania. 8. Department of Internal Medicine, "Fundeni" Clinical Institute, Bucharest, Romania. 9. Department of Obstetrics and Gynecology, "St. John" Emergency Clinical Hospital, Bucharest, Romania. 10. Department of Surgery, "Pantelimon" Clinical Hospital, Bucharest, Romania. 11. Department of Urology, Emergency Central Military Hospital, Academy of Romanian Scientists, Bucharest, Romania. 12. Department of Surgery, "Ponderas" Academic Hospital, Bucharest, Romania.
Abstract
BACKGROUND/AIM: Malignant transformation of mature cystic ovarian teratoma is a scarce eventuality, only rare cases being reported so far. Furthermore, development of this transformation in the setting of an abscessed tumor is even scarcer. The aim of this study was to report the case of a 47-year-old patient submitted to surgery for such a lesion. CASE REPORT: The patient was investigated for diffuse pelvic pain and diagnosed with a 10×7×8 cm mass at the level of the left adnexa with imaging findings suggesting the presence of an ovarian teratoma. The patient was submitted to surgery involving a total hysterectomy with bilateral adnexectomy, lymphadenectomy and peritoneal biopsies. The histopathological examination demonstrated the presence of squamous cell carcinoma areas transformation in association with areas of abscess. Postoperatively the patient was submitted to six cycles of platinum-based chemotherapy and concurrent external radiotherapy. At one-year follow-up she is free of recurrent disease. CONCLUSION: Although malignisation of mature cystic ovarian teratoma is a rare event, it should not be omitted when mature ovarian teratoma is suspected; however, association between malignant transformation and abscess is a scarcer eventuality. Copyright
BACKGROUND/AIM: Malignant transformation of mature cystic ovarian teratoma is a scarce eventuality, only rare cases being reported so far. Furthermore, development of this transformation in the setting of an abscessed tumor is even scarcer. The aim of this study was to report the case of a 47-year-old patient submitted to surgery for such a lesion. CASE REPORT: The patient was investigated for diffuse pelvic pain and diagnosed with a 10×7×8 cm mass at the level of the left adnexa with imaging findings suggesting the presence of an ovarian teratoma. The patient was submitted to surgery involving a total hysterectomy with bilateral adnexectomy, lymphadenectomy and peritoneal biopsies. The histopathological examination demonstrated the presence of squamous cell carcinoma areas transformation in association with areas of abscess. Postoperatively the patient was submitted to six cycles of platinum-based chemotherapy and concurrent external radiotherapy. At one-year follow-up she is free of recurrent disease. CONCLUSION: Although malignisation of mature cystic ovarian teratoma is a rare event, it should not be omitted when mature ovarian teratoma is suspected; however, association between malignant transformation and abscess is a scarcer eventuality. Copyright
Authors: C J Tseng; H H Chou; K G Huang; T C Chang; C C Liang; C H Lai; Y K Soong; S Hsueh; C C Pao Journal: Gynecol Oncol Date: 1996-12 Impact factor: 5.482
Authors: S Tangjitgamol; S Manusirivithaya; C Sheanakul; S Leelahakorn; T Thawaramara; S Jesadapatarakul Journal: Int J Gynecol Cancer Date: 2003 Jul-Aug Impact factor: 3.437