Takeshi Numata1, Takeo Endo1, Hidetoshi Yanai1, Kyoko Ota1, Yusuke Yamamoto2, Kei Shimizu2, Hideyasu Yamada3, Kenji Hayashihara4, Shinichiro Okauchi5, Hiroaki Satoh6, Yutaka Yamada7, Tomohiro Tamura7, Kazuto Saito8, Norihiro Kikuchi9, Koichi Kurishima10, Hiroichi Ishikawa10, Hiroko Watanabe11, Toshihiro Shiozawa12, Nobuyuki Hizawa12, Yasunori Funayama13, Shigen Hayashi14, Hiroyuki Nakamura15, Takaaki Yamashita16. 1. Division of Respiratory Medicine, Mito Medical Center, Ibaraki-machi, Japan. 2. Division of Respiratory Medicine, Hitachi General Hospital, Hitachi, Japan. 3. Division of Respiratory Medicine, Hitachinaka Medical Center-Hitachinaka Medical Center, University of Tsukuba, Hitachinaka, Japan. 4. Division of Respiratory Medicine, Ibarakihigashi Hospital, Tokai, Japan. 5. Division of Respiratory Medicine, Mito Kyodo General Hospital-Mito Medical Center, University of Tsukuba, Mito, Japan. 6. Division of Respiratory Medicine, Mito Kyodo General Hospital-Mito Medical Center, University of Tsukuba, Mito, Japan hirosato@md.tsukuba.ac.jp. 7. Respiratory Center, Ibaraki Prefectural Central Hospital, Kasama, Japan. 8. Division of Respiratory Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura, Japan. 9. Division of Respiratory Medicine, Kasumigaura Medical Center Hospital, Tsuchiura, Japan. 10. Division of Respiratory Medicine, Tsukuba Medical Center Hospital, Tsukuba, Japan. 11. Division of Thoracic Surgery, Tsukuba Kinen Hospital, Tsukuba, Japan. 12. Faculty of Clinical Medicine, University of Tsukuba, Tsukuba, Japan. 13. Division of Respiratory Medicine, Tsukuba Gakuen General Hospital, Tsukuba, Japan. 14. Division of Respiratory Medicine, Ibaraki Seinan Medical Center Hospital, Sakai-machi, Japan. 15. Division of Respiratory Medicine, Tokyo Medical University, Ibaraki Medical Center, Ami-machi, Japan. 16. Division of Respiratory Medicine, JA Toride Medical Center Hospital, Toride, Japan.
Abstract
AIM: To clarify the correlation between serum levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA) and metastasis and survival in anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS: CEA and CYFRA levels in 131 ALK-rearranged NSCLC patients were determined using fluorescence in situ hybridization (FISH), real time-reverse transcription polymerase chain reaction, and immunohistochemistry, using biopsy specimens, cytology specimens, and plasma specimens. Cut-off value of each marker was determined as 10 ng/ml. RESULTS: In logistic regression analysis, higher levels of both markers had a positive relationship with bone metastases, and higher levels of CYFRA was relevant to liver metastases, and multiple-organ metastases. However, these markers were not proven to be poor prognostic factors in Cox's proportional model analysis. CONCLUSION: Elevated serum CEA and CYFRA levels seem to provide useful clinical information about presence of bone and liver metastasis and multiple-organ metastases, although they were not a powerful indicator of prognosis. These two markers may suggest the extension of metastasis and would be helpful in considering treatment options. Copyright
AIM: To clarify the correlation between serum levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA) and metastasis and survival in anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS: CEA and CYFRA levels in 131 ALK-rearranged NSCLC patients were determined using fluorescence in situ hybridization (FISH), real time-reverse transcription polymerase chain reaction, and immunohistochemistry, using biopsy specimens, cytology specimens, and plasma specimens. Cut-off value of each marker was determined as 10 ng/ml. RESULTS: In logistic regression analysis, higher levels of both markers had a positive relationship with bone metastases, and higher levels of CYFRA was relevant to liver metastases, and multiple-organ metastases. However, these markers were not proven to be poor prognostic factors in Cox's proportional model analysis. CONCLUSION: Elevated serum CEA and CYFRA levels seem to provide useful clinical information about presence of bone and liver metastasis and multiple-organ metastases, although they were not a powerful indicator of prognosis. These two markers may suggest the extension of metastasis and would be helpful in considering treatment options. Copyright
Authors: Helga Sertić Milić; Ana Franjević; Gordana Bubanović; Ante Marušić; Igor Nikolić; Igor Puljić Journal: Wien Klin Wochenschr Date: 2015-04-28 Impact factor: 1.704
Authors: A K Ayan; B Erdemci; E Orsal; Z Bayraktutan; E Akpinar; A Topcu; M Turkeli; B Seven Journal: Rev Esp Med Nucl Imagen Mol Date: 2015-10-27 Impact factor: 1.359