Marco Zschoche1, Annette Zimpfer2, Björn O Scheef3, Anselm M Jünemann3, Rudolf F Guthoff3, Christian Junghanss4, Guido Hildebrandt5, Steffen Emmert6, Andreas Erbersdobler2, Günther Kundt7, Vinodh Kakkassery1,8. 1. Department of Ophthalmology, University Medical Center Rostock, Rostock, Germany vinodh.kakkassery@gmail.com marco.zschoche@gmail.com. 2. Institute of Pathology, University Medical Center Rostock, Rostock, Germany. 3. Department of Ophthalmology, University Medical Center Rostock, Rostock, Germany. 4. Department of Oncology, University Medical Center Rostock, Rostock, Germany. 5. Department of Radiotherapy, University Medical Center Rostock, Rostock, Germany. 6. Clinic and Polyclinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany. 7. Institute for Biostatistics and Informatics in Medicine and Ageing Research, University of Rostock, Rostock, Germany. 8. Department of Ophthalmology, University-Hospital Schleswig-Holstein, University of Luebeck, Luebeck, Germany.
Abstract
BACKGROUND: To evaluate biodata, symptoms/signs, lymphoma type, localization, stage level, treatment choice and outcome of ocular adnexal lymphoma (OAL). PATIENTS AND METHODS: A single-center retrospective analysis of 56 patients with OAL was performed from 1998 to 2018. RESULTS: OAL involved the orbit in 44.6%, the conjunctiva in 32.1%, the lacrimal apparatus in 14.3% and the eyelid in 8.93%. Extranodal marginal zone B-cell lymphoma (EMZL) was found in 60.7%, follicular lymphoma (FL) in 21.4%, diffuse large B-cell lymphoma in 7.14%, mantle cell lymphoma in 5.36% and chronic lymphatic leukaemia in 5.36% patients. No relapse was seen in 76%. EMZL and FL had a significantly better overall survival compared to other lymphoma types (p=0.002). Patients with Ann Arbor stage IE had a significantly better prognosis than those with stages higher than IE (p=0.048). CONCLUSION: Our data suggest that clinicopathological features such as Ann Arbor stage influence survival. Copyright
BACKGROUND: To evaluate biodata, symptoms/signs, lymphoma type, localization, stage level, treatment choice and outcome of ocular adnexal lymphoma (OAL). PATIENTS AND METHODS: A single-center retrospective analysis of 56 patients with OAL was performed from 1998 to 2018. RESULTS: OAL involved the orbit in 44.6%, the conjunctiva in 32.1%, the lacrimal apparatus in 14.3% and the eyelid in 8.93%. Extranodal marginal zone B-cell lymphoma (EMZL) was found in 60.7%, follicular lymphoma (FL) in 21.4%, diffuse large B-cell lymphoma in 7.14%, mantle cell lymphoma in 5.36% and chronic lymphatic leukaemia in 5.36% patients. No relapse was seen in 76%. EMZL and FL had a significantly better overall survival compared to other lymphoma types (p=0.002). Patients with Ann Arbor stage IE had a significantly better prognosis than those with stages higher than IE (p=0.048). CONCLUSION: Our data suggest that clinicopathological features such as Ann Arbor stage influence survival. Copyright
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