Literature DB >> 32604411

Outcomes of Reflex Cryptococcal Antigen (CrAg) Screening in Human Immunodeficiency Virus (HIV)-Positive Patients With CD4 Counts of 100-200 Cells/µL in Botswana.

Mark W Tenforde1,2,3, Thandi Milton3, Ikanyeng Rulaganyang3, Charles Muthoga3,4, Leabaneng Tawe3, Tom Chiller5, Gregory Greene5, Alexander Jordan5, Christopher G Williams4, Leah Owen3, Tshepo B Leeme3,4, Amber Boose3, Julia Ngidi4, Madisa Mine6, Joseph N Jarvis3,4,7.   

Abstract

Increasing the CD4-count threshold for cryptococcal antigen (CrAg) screening from ≤100 to ≤200 cells/µL resulted in a 3-fold increase in numbers screened. CrAg-prevalence was 3.5% at CD4 101-200 and 6.2% ≤100 cells/µL. Six-month mortality was 21.4% (9/42) in CrAg-positive CD4 ≤100 cells/µL and 3.2% (1/31) in CrAg-positive CD4 101-200 cells/µL.
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  HIV treat all; HIV/AIDS; advanced HIV; antiretroviral therapy; cryptococcal antigen

Mesh：

Substances：

Year:  2021        PMID： 32604411      PMCID： PMC8096249          DOI： 10.1093/cid/ciaa899

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  9 in total

1.  Lumbar puncture refusal in sub-Saharan Africa: A call for further understanding and intervention.

Authors:  Kiran T Thakur; Kondwelani Mateyo; Lottie Hachaambwa; Violet Kayamba; Macpherson Mallewa; Jane Mallewa; Ernest O Nwazor; Tope Lawal; Chindo B Mallum; Masharip Atadzhanov; David R Boulware; Gretchen L Birbeck; Omar K Siddiqi
Journal:  Neurology       Date:  2015-05-12       Impact factor: 9.910

2.  Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis.

Authors:  Radha Rajasingham; Rachel M Smith; Benjamin J Park; Joseph N Jarvis; Nelesh P Govender; Tom M Chiller; David W Denning; Angela Loyse; David R Boulware
Journal:  Lancet Infect Dis       Date:  2017-05-05       Impact factor: 25.071

3.  Impact of Routine Cryptococcal Antigen Screening and Targeted Preemptive Fluconazole Therapy in Antiretroviral-naive Human Immunodeficiency Virus-infected Adults With CD4 Cell Counts <100/μL: A Systematic Review and Meta-analysis.

Authors:  Elvis Temfack; Jean Joel Bigna; Henry N Luma; Rene Spijker; Graeme Meintjes; Joseph N Jarvis; Françoise Dromer; Thomas Harrison; Jérémie F Cohen; Olivier Lortholary
Journal:  Clin Infect Dis       Date:  2019-02-01       Impact factor: 9.079

4.  Cryptococcal meningitis screening and community-based early adherence support in people with advanced HIV infection starting antiretroviral therapy in Tanzania and Zambia: an open-label, randomised controlled trial.

Authors:  Sayoki Mfinanga; Duncan Chanda; Sokoine L Kivuyo; Lorna Guinness; Christian Bottomley; Victoria Simms; Carol Chijoka; Ayubu Masasi; Godfather Kimaro; Bernard Ngowi; Amos Kahwa; Peter Mwaba; Thomas S Harrison; Saidi Egwaga; Shabbar Jaffar
Journal:  Lancet       Date:  2015-03-10       Impact factor: 79.321

5.  Screening for cryptococcal antigenemia in patients accessing an antiretroviral treatment program in South Africa.

Authors:  Joseph N Jarvis; Stephen D Lawn; Monica Vogt; Nonzwakazi Bangani; Robin Wood; Thomas S Harrison
Journal:  Clin Infect Dis       Date:  2009-04-01       Impact factor: 9.079

6.  High Cryptococcal Antigen Titers in Blood Are Predictive of Subclinical Cryptococcal Meningitis Among Human Immunodeficiency Virus-Infected Patients.

Authors:  Rachel M Wake; Erika Britz; Charlotte Sriruttan; Ivy Rukasha; Tanvier Omar; David C Spencer; Jeremy S Nel; Sello Mashamaite; Adeboye Adelekan; Tom M Chiller; Joseph N Jarvis; Thomas S Harrison; Nelesh P Govender
Journal:  Clin Infect Dis       Date:  2018-02-10       Impact factor: 9.079

7.  Prevalence and Sequelae of Cryptococcal Antigenemia in Antiretroviral Therapy-Experienced Populations: An Evaluation of Reflex Cryptococcal Antigen Screening in Botswana.

Authors:  William J Hurt; Mark W Tenforde; Mooketsi Molefi; Hannah K Mitchell; Thandi Milton; Martin S Azama; Irene Goercke; Fredah Mulenga; Nametso Tlhako; Katlego Tsholo; Tuhina Srivastava; Tshepo B Leeme; Godfrey Simoonga; Charles Muthoga; Kwana Lechiile; Madisa Mine; Joseph N Jarvis
Journal:  Clin Infect Dis       Date:  2021-05-18       Impact factor: 9.079

8.  HIV-Associated Cryptococcal Meningitis Occurring at Relatively Higher CD4 Counts.

Authors:  Lillian Tugume; Joshua Rhein; Kathy Huppler Hullsiek; Edward Mpoza; Reuben Kiggundu; Kenneth Ssebambulidde; Charlotte Schutz; Kabanda Taseera; Darlisha A Williams; Mahsa Abassi; Conrad Muzoora; Abdu K Musubire; Graeme Meintjes; David B Meya; David R Boulware
Journal:  J Infect Dis       Date:  2019-02-23       Impact factor: 5.226

9.  CD4 Cell Count Threshold for Cryptococcal Antigen Screening of HIV-Infected Individuals: A Systematic Review and Meta-analysis.

Authors:  Nathan Ford; Zara Shubber; Joseph N Jarvis; Tom Chiller; Greg Greene; Chantal Migone; Marco Vitoria; Meg Doherty; Graeme Meintjes
Journal:  Clin Infect Dis       Date:  2018-03-04       Impact factor: 9.079
  9 in total
  1 in total

1.  Five years after Treat All implementation: Botswana's HIV response and future directions in the era of COVID-19.

Authors:  Keith Jefferis; Ava Avalos; Heston Phillips; Mpho Mmelesi; Dinah Ramaabya; Bornapate Nkomo; Charles Muthoga; Joseph N Jarvis; Siphiwe Ratladi; Robert Selato; John Stover
Journal:  South Afr J HIV Med       Date:  2021-10-15       Impact factor: 2.744
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.