Literature DB >> 32603470

Acquired Long QT Syndrome after Acute Myocardial Infarction: A Rare but Potentially Fatal Entity.

Samuel S Gordon1, John Hollowed2, Justin Hayase2, Carlos Macias2, Jessica Wang2, Holly R Middlekauff2.   

Abstract

Acquired long QT syndrome is typically caused by medications, electrolyte disturbances, bradycardia, or catastrophic central nervous system events. We report a case of myocardial infarction-related acquired long QT syndrome in a 58-year-old woman that had no clear cause and progressed to torsades de pointes requiring treatment with isoproterenol and magnesium. Despite negative results of DNA testing against a known panel of genetic mutations and polymorphisms associated with long QT syndrome, the patient's family history of fatal cardiac disease suggests a predisposing genetic component. This report serves to remind clinicians of this potentially fatal ventricular arrhythmia after myocardial infarction.
© 2020 by the Texas Heart® Institute, Houston.

Entities:  

Keywords:  Long QT syndrome/etiology/genetics; myocardial infarction; torsades de pointes

Year:  2020        PMID: 32603470      PMCID: PMC7328093          DOI: 10.14503/THIJ-18-6872

Source DB:  PubMed          Journal:  Tex Heart Inst J        ISSN: 0730-2347


  6 in total

Review 1.  Acquired long QT syndrome and torsade de pointes.

Authors:  Nabil El-Sherif; Gioia Turitto; Mohamed Boutjdir
Journal:  Pacing Clin Electrophysiol       Date:  2018-03-30       Impact factor: 1.976

2.  Early afterdepolarizations and triggered activity in rabbit cardiac Purkinje fibers recovering from ischemic-like conditions. Role of acidosis.

Authors:  G J Rozanski; R C Witt
Journal:  Circulation       Date:  1991-04       Impact factor: 29.690

3.  Torsades de pointes following acute myocardial infarction: evidence for a deadly link with a common genetic variant.

Authors:  Lia Crotti; Dan Hu; Hector Barajas-Martinez; Gaetano M De Ferrari; Antonio Oliva; Roberto Insolia; Guido D Pollevick; Federica Dagradi; Alejandra Guerchicoff; Federica Greco; Peter J Schwartz; Sami Viskin; Charles Antzelevitch
Journal:  Heart Rhythm       Date:  2012-02-13       Impact factor: 6.343

4.  Pause-dependent torsade de pointes following acute myocardial infarction: a variant of the acquired long QT syndrome.

Authors:  A Halkin; A Roth; I Lurie; R Fish; B Belhassen; S Viskin
Journal:  J Am Coll Cardiol       Date:  2001-10       Impact factor: 24.094

Review 5.  Clinical relevance of cardiac arrhythmias generated by afterdepolarizations. Role of M cells in the generation of U waves, triggered activity and torsade de pointes.

Authors:  C Antzelevitch; S Sicouri
Journal:  J Am Coll Cardiol       Date:  1994-01       Impact factor: 24.094

6.  QT interval prolongation in acute myocardial infarction.

Authors:  S Ahnve
Journal:  Eur Heart J       Date:  1985-11       Impact factor: 29.983

  6 in total

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