Literature DB >> 3260310

Growth factor involvement and oncogene expression in prostatic tumours.

C L Eaton1, P Davies, M E Phillips.   

Abstract

The effects of EGF, TGF alpha and 5 alpha-dihydrotestosterone on the growth of a prostatic epithelial cell line have been evaluated in clonal growth assays. Similar bioassay systems have been used to identify tumour-associated growth promoters derived from a human prostatic carcinoma cell line (PC3). Growth factor activity was associated with proteins of Mr 20-30 kDa. In a separate study, EGF receptor concentration and cellular proto-oncogene expression was assessed in prostatic tumour samples. In prostatic carcinoma samples, strong correlation was observed between EGF receptor concentration and c-myc expression. There were no significant correlations between EGF receptor concentration and tumour grade or androgen receptor content in carcinoma samples. EGF receptor concentration was significantly higher in prostatic carcinoma specimens than in BPH.

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Year:  1988        PMID： 3260310     DOI： 10.1016/0022-4731(88)90120-3

Source DB:  PubMed          Journal:  J Steroid Biochem        ISSN： 0022-4731            Impact factor:   4.292


  8 in total

1.  EGF receptor signaling enhances in vivo invasiveness of DU-145 human prostate carcinoma cells.

Authors:  T Turner; P Chen; L J Goodly; A Wells
Journal:  Clin Exp Metastasis       Date:  1996-09       Impact factor: 5.150

Review 2.  Growth factors as mediators of androgen action during the development of the male urogenital tract.

Authors:  G R Cunha; B Foster; A Thomson; Y Sugimura; N Tanji; M Tsuji; N Terada; P W Finch; A A Donjacour
Journal:  World J Urol       Date:  1995       Impact factor: 4.226

3.  Expression of mRNA for epidermal growth factor, transforming growth factor-alpha and their receptor in human prostate tissue and cell lines.

Authors:  K Z Ching; E Ramsey; N Pettigrew; R D'Cunha; M Jason; J G Dodd
Journal:  Mol Cell Biochem       Date:  1993-09-22       Impact factor: 3.396

Review 4.  Prostate cancer progression. Implications of histopathology.

Authors:  J L Ware
Journal:  Am J Pathol       Date:  1994-11       Impact factor: 4.307

Review 5.  Growth factors and their receptors as determinants in the proliferation and metastasis of human prostate cancer.

Authors:  J L Ware
Journal:  Cancer Metastasis Rev       Date:  1993-09       Impact factor: 9.264

6.  In vitro invasiveness of DU-145 human prostate carcinoma cells is modulated by EGF receptor-mediated signals.

Authors:  H Xie; T Turner; M H Wang; R K Singh; G P Siegal; A Wells
Journal:  Clin Exp Metastasis       Date:  1995-11       Impact factor: 5.150

7.  Epidermal growth factor receptor content in rat prostatic adenocarcinoma: effects of endocrine treatment.

Authors:  J E Damber; A Bergh; B Assarsson; M Gåfvels
Journal:  Urol Res       Date:  1995

8.  Epidermal growth factor receptors in human prostate cancer: correlation with histological differentiation of the tumour.

Authors:  S Q Maddy; G D Chisholm; A Busuttil; F K Habib
Journal:  Br J Cancer       Date:  1989-07       Impact factor: 7.640
  8 in total

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