Literature DB >> 32602725

Palladium-Catalyzed N-Acylation of Tertiary Amines by Carboxylic Acids: A Method for the Synthesis of Amides.

Zhaohui Li1, Long Liu1, Kaiqiang Xu1, Tianzeng Huang1, Xinyi Li1, Bin Song1, Tieqiao Chen1.   

Abstract

A palladium-catalyzed N-acylation of tertiary amines by carboxylic acids was achieved through C-N cleavage. This reaction showed a wide substrate scope. Both aromatic and aliphatic acids served well as the acylating reagents and coupled with tertiary amines to produce the corresponding amides in good to excellent yields. With the strategy, bioactive carboxylic acids were also efficiently modified, highlighting the synthetic value of the process in organic synthesis.

Entities:  

Year:  2020        PMID： 32602725     DOI： 10.1021/acs.orglett.0c01869

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Base-promoted direct amidation of esters: beyond the current scope and practical applications.

Authors:  Ivaylo Slavchev; Jas S Ward; Kari Rissanen; Georgi M Dobrikov; Svilen Simeonov
Journal:  RSC Adv       Date:  2022-07-15       Impact factor: 4.036

2.  Copper(II)-β-cyclodextrin immobilized on graphitic carbon nitride nanosheets as a highly effective catalyst for tandem oxidative amidation of benzylic alcohols.

Authors:  Hossein Ghafuri; Afsaneh Rashidizadeh; Mostafa Ghafori Gorab; Ghazaleh Jafari
Journal:  Sci Rep       Date:  2022-02-11       Impact factor: 4.996

3.  Methyltrimethoxysilane (MTM) as a Reagent for Direct Amidation of Carboxylic Acids.

Authors:  D Christopher Braddock; Joshua J Davies; Paul D Lickiss
Journal:  Org Lett       Date:  2022-01-27       Impact factor: 6.005
  3 in total

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