Literature DB >> 3260266

Granulocyte elastase cleaves human high molecular weight kininogen and destroys its clot-promoting activity.

J Kleniewski1, V Donaldson.   

Abstract

Purified human granulocyte elastase cleaved purified human high molecular weight (HMW) kininogen into multiple low molecular weight fragments, and destroyed the clot-promoting activity of the HMW kininogen. Elastase digestion did not release kinin or destroy the bradykinin portion of the HMW kininogen molecule; kallikrein could release kinin from the elastase-induced low molecular weight digestion products of HMW kininogen. Purified alpha 1-antitrypsin prevented the destruction of the clot-promoting activity of HMW kininogen by elastase; it also delayed the clotting of normal plasma. Elastase may play a significant role in altered hemostasis as well as fibrinolysis, in areas of inflammation to which polymorphonuclear leukocytes have been attracted.

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Year:  1988        PMID： 3260266      PMCID： PMC2189673          DOI： 10.1084/jem.167.6.1895

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  42 in total

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Authors:  V H Donaldson; J Kleniewski
Journal:  Thromb Res       Date:  1979       Impact factor: 3.944

2.  Inhibition by C1INH of Hagemann factor fragment activation of coagulation, fibrinolysis, and kinin generation.

Authors:  A D Schreiber; A P Kaplan; K F Austen
Journal:  J Clin Invest       Date:  1973-06       Impact factor: 14.808

3.  Inhibition of activated Hageman factor and activated plasma thromboplastin antecedent by purified serum C1 inactivator.

Authors:  C D Forbes; J Pensky; O D Ratnoff
Journal:  J Lab Clin Med       Date:  1970-11

Review 4.  Leukocyte elastase.

Authors:  A J Barrett
Journal:  Methods Enzymol       Date:  1981       Impact factor: 1.600

5.  Leukocyte elastase release during blood coagulation. A potential mechanism for activation of the alternative fibrinolytic pathway.

Authors:  E F Plow
Journal:  J Clin Invest       Date:  1982-03       Impact factor: 14.808

6.  Williams trait. Human kininogen deficiency with diminished levels of plasminogen proactivator and prekallikrein associated with abnormalities of the Hageman factor-dependent pathways.

Authors:  R W Colman; A Bagdasarian; R C Talamo; C F Scott; M Seavey; J A Guimaraes; J V Pierce; A P Kaplan
Journal:  J Clin Invest       Date:  1975-12       Impact factor: 14.808

7.  Kininogen deficiency in Fitzgerald trait: role of high molecular weight kininogen in clotting and fibrinolysis.

Authors:  V H Donaldson; H I Glueck; M A Miller; H Z Movat; F Habal
Journal:  J Lab Clin Med       Date:  1976-02

8.  Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase.

Authors:  M S Brower; P C Harpel
Journal:  J Biol Chem       Date:  1982-08-25       Impact factor: 5.157

9.  Substrates of Hageman factor. I. Isolation and characterization of human factor XI (PTA) and inhibition of the activated enzyme by alpha 1-antitrypsin.

Authors:  L W Heck; A P Kaplan
Journal:  J Exp Med       Date:  1974-12-01       Impact factor: 14.307

10.  The inhibition of plasmin, plasma kallikrein, plasma permeability factor, and the C'1r subcomponent of the first component of complement by serum C'1 esterase inhibitor.

Authors:  O D Ratnoff; J Pensky; D Ogston; G B Naff
Journal:  J Exp Med       Date:  1969-02-01       Impact factor: 14.307
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  5 in total

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Authors:  E J Gustafson; A H Schmaier; Y T Wachtfogel; N Kaufman; U Kucich; R W Colman
Journal:  J Clin Invest       Date:  1989-07       Impact factor: 14.808

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Authors:  R A Pixley; R A DeLa Cadena; J D Page; N Kaufman; E G Wyshock; R W Colman; A Chang; F B Taylor
Journal:  Am J Pathol       Date:  1992-04       Impact factor: 4.307

Review 3.  The Mast Cell, Contact, and Coagulation System Connection in Anaphylaxis.

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Journal:  Front Immunol       Date:  2017-07-26       Impact factor: 7.561

Review 4.  Processing of Factor XII during Inflammatory Reactions.

Authors:  Bernard Nico Jukema; Steven de Maat; Coen Maas
Journal:  Front Med (Lausanne)       Date:  2016-11-04

Review 5.  Roles of Immune Cells in Hereditary Angioedema.

Authors:  Anne Lise Ferrara; Leonardo Cristinziano; Angelica Petraroli; Maria Bova; Maria Celeste Gigliotti; Simone Marcella; Luca Modestino; Gilda Varricchi; Mariantonia Braile; Maria Rosaria Galdiero; Giuseppe Spadaro; Stefania Loffredo
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  5 in total

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