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Literature DB >> 32602512

Viscoelasticity of hydrazone crosslinked poly(ethylene glycol) hydrogels directs chondrocyte morphology during mechanical deformation.

Benjamin M Richardson¹, Cierra J Walker, Laura J Macdougall, Jack W Hoye, Mark A Randolph, Stephanie J Bryant, Kristi S Anseth.

Abstract

Chondrocyte deformation influences disease progression and tissue regeneration in load-bearing joints. In this work, we found that viscoelasticity of dynamic covalent crosslinks temporally modulates the biophysical transmission of physiologically relevant compressive strains to encapsulated chondrocytes. Chondrocytes in viscoelastic alky-hydrazone hydrogels demonstrated (91.4 ± 4.5%) recovery of native rounded morphologies during mechanical deformation, whereas primarily elastic benzyl-hydrazone hydrogels significantly limited morphological recovery (21.2 ± 1.4%).

Entities: Chemical

Mesh：

Substances：

Year: 2020 PMID： 32602512 PMCID： PMC8908465 DOI： 10.1039/d0bm00860e

Source DB: PubMed Journal: Biomater Sci ISSN： 2047-4830 Impact factor: 6.843

40 in total

Review 1. Biology of fibrocartilage cells.

Authors: M Benjamin; J R Ralphs
Journal: Int Rev Cytol Date: 2004

2. Changes in the ratio of type-I and type-II collagen expression during monolayer culture of human chondrocytes.

Authors: S Marlovits; M Hombauer; M Truppe; V Vècsei; W Schlegel
Journal: J Bone Joint Surg Br Date: 2004-03

3. Hydrolytic stability of hydrazones and oximes.

Authors: Jeet Kalia; Ronald T Raines
Journal: Angew Chem Int Ed Engl Date: 2008 Impact factor: 15.336

4. The development and characterization of an in vitro system to study strain-induced cell deformation in isolated chondrocytes.

Authors: D A Lee; D L Bader
Journal: In Vitro Cell Dev Biol Anim Date: 1995-12 Impact factor: 2.416

2. Mechanobiological Interactions between Dynamic Compressive Loading and Viscoelasticity on Chondrocytes in Hydrazone Covalent Adaptable Networks for Cartilage Tissue Engineering.

Authors: Benjamin M Richardson; Cierra J Walker; Mollie M Maples; Mark A Randolph; Stephanie J Bryant; Kristi S Anseth
Journal: Adv Healthc Mater Date: 2021-03-18 Impact factor: 9.933

2 in total

Viscoelasticity of hydrazone crosslinked poly(ethylene glycol) hydrogels directs chondrocyte morphology during mechanical deformation.

Review 1. Biology of fibrocartilage cells.

2. Changes in the ratio of type-I and type-II collagen expression during monolayer culture of human chondrocytes.

3. Hydrolytic stability of hydrazones and oximes.

4. The development and characterization of an in vitro system to study strain-induced cell deformation in isolated chondrocytes.

Review 5. Mechanical properties of hydrogels and their experimental determination.

Review 6. Unlike bone, cartilage regeneration remains elusive.

7. Hydrogels with Reversible Mechanics to Probe Dynamic Cell Microenvironments.

Review 8. Adaptable hydrogel networks with reversible linkages for tissue engineering.

9. The basic science of articular cartilage: structure, composition, and function.

10. Mechanical confinement regulates cartilage matrix formation by chondrocytes.

1. Using Stereochemistry to Control Mechanical Properties in Thiol-Yne Click-Hydrogels.

2. Mechanobiological Interactions between Dynamic Compressive Loading and Viscoelasticity on Chondrocytes in Hydrazone Covalent Adaptable Networks for Cartilage Tissue Engineering.