C Romero-Blanco1,2, M J Artiga González3, A Gómez-Cabello4, S Vila-Maldonado5, J A Casajús4, I Ara2,5, S Aznar1,2. 1. PAFS Research Group (Physical Activity and Health Promotion Research Group), Universidad de Castilla-La Mancha, Toledo, Spain. 2. CIBERFES Research Group (Centro de Investigación Biomédica en Red. Fragilidad y Envejecimiento Saludable), Madrid, Spain. 3. Biobank Department, Spanish National Cancer Center (CNIO), Madrid, Spain. 4. GENUD Research Group (Growth, Exercise, Nutrition and Development Research Group), University of Zaragoza, Zaragoza, Spain. 5. GENUD Toledo Research Group (Growth, Exercise, Nutrition and Development Research Group), Universidad de Castilla-La Mancha, Toledo, Spain.
Abstract
BACKGROUND: As the population is getting older, physical activity promotion becomes a good strategy to increase quality of life in the elderly; but genetic condition also plays an important role. The purpose of this study was to examine the association of the ACTN3 R577X polymorphism with physical fitness and muscle mass in physically active older women. METHODS: A cross-sectional study was performed with two groups of older women who practiced physical exercise regularly. The first cohort comprised 164 women (age 69.7 ± 3.2 years) and the second cohort 131 women (age 78.5 ± 3.0 years). The main outcome measures were anthropometric measures with assessment of sarcopenia and sarcopenic obesity, self-reported physical activity EXERNET questionnaire (EEPAQ), evaluation of physical fitness (muscle strength and flexibility test), and ACTN3 genotyping. RESULTS: Women above 75 years old with allele R presented a higher risk of experiencing sarcopenia compared to ACTNR XX homozygous women (odds ratio 0.356, 95% confidence interval 0.139-0.915, p = 0.026). Furthermore, statistically significant differences were found in the chair stand test (p = 0.04), as well as in the sit and reach test (p = 0.01), with better results for women below 75 years old with the ACTN3 XX genotype. CONCLUSIONS: Sarcopenia and physical fitness show differences based on the ACTN3 R577X genotype in active older women.
BACKGROUND: As the population is getting older, physical activity promotion becomes a good strategy to increase quality of life in the elderly; but genetic condition also plays an important role. The purpose of this study was to examine the association of the ACTN3R577X polymorphism with physical fitness and muscle mass in physically active older women. METHODS: A cross-sectional study was performed with two groups of older women who practiced physical exercise regularly. The first cohort comprised 164 women (age 69.7 ± 3.2 years) and the second cohort 131 women (age 78.5 ± 3.0 years). The main outcome measures were anthropometric measures with assessment of sarcopenia and sarcopenic obesity, self-reported physical activity EXERNET questionnaire (EEPAQ), evaluation of physical fitness (muscle strength and flexibility test), and ACTN3 genotyping. RESULTS:Women above 75 years old with allele R presented a higher risk of experiencing sarcopenia compared to ACTNR XX homozygous women (odds ratio 0.356, 95% confidence interval 0.139-0.915, p = 0.026). Furthermore, statistically significant differences were found in the chair stand test (p = 0.04), as well as in the sit and reach test (p = 0.01), with better results for women below 75 years old with the ACTN3 XX genotype. CONCLUSIONS:Sarcopenia and physical fitness show differences based on the ACTN3R577X genotype in active older women.
Entities:
Keywords:
ACTN3; aged; genotype; lifestyle; physical fitness; women
Authors: Praval Khanal; Lingxiao He; Adam J Herbert; Georgina K Stebbings; Gladys L Onambele-Pearson; Hans Degens; Christopher I Morse; Martine Thomis; Alun G Williams Journal: Genes (Basel) Date: 2020-12-05 Impact factor: 4.096
Authors: Arben Boshnjaku; Ermira Krasniqi; Harald Tschan; Barbara Wessner Journal: Int J Environ Res Public Health Date: 2021-08-30 Impact factor: 3.390