| Literature DB >> 32600716 |
Simona Clichici1, Luminita David2, Bianca Moldovan3, Ioana Baldea1, Diana Olteanu1, Mara Filip1, Andras Nagy4, Vlad Luca5, Carmen Crivii6, Petru Mircea7, Gabriel Katona8, Gabriela Adriana Filip1.
Abstract
The present study reports the green synthesis of hybrid organic-inorganic gold nanocomposites using silymarin as reducing and capping agent. The structure of the silymarin loaded gold nanoparticles was investigated by using the appropriate analysis tools such as UV-Vis and Fourier-transform infrared spectroscopy (FTIR), and Transmission electron microscopy (TEM) techniques. TEM micrographs demonstrated that the gold nanoparticles were spherical in shape, well distributed and their mean size was about 10 nm. The in vivo hepatoprotective and antifibrogenic properties after bile duct ligation in rats of the silymarin coated gold nanoparticles were assessed. The changes regarding the blood tests and the liver histopathology were compared to the standard administration of silymarin. Silymarin loaded gold nanoparticles improved liver function, reduced cholestasis and oxidative stress parameters, with the increase of antioxidant support, and reduced inflammation and fibrosis in the liver of rats with extrahepatic cholestasis.Entities:
Keywords: Cholestasis; Gold nanoparticles; Hepatoprotective agent; Silymarin
Year: 2020 PMID： 32600716 DOI： 10.1016/j.msec.2020.111117
Source DB: PubMed Journal: Mater Sci Eng C Mater Biol Appl ISSN： 0928-4931 Impact factor: 7.328