Literature DB >> 32600092

Leaky memories: Impact of APOE4 on blood-brain barrier and dementia.

Wenlu Li1, Eng H Lo1.   

Abstract

A new study suggests that the leading genetic risk factor for Alzheimer's disease, apolipoprotein E4 (APOE4), is linked to blood-brain barrier breakdown and subsequent cognitive decline. These findings broaden our understanding of how cerebrovascular mechanisms contribute to cognitive impairment and should stimulate new directions for pursuing therapeutic approaches for Alzheimer's disease and related dementias.

Entities:  

Keywords:  Alzheimer’s disease; apolipoprotein E4; blood–brain barrier; dementia; pericyte degeneration

Year:  2020        PMID： 32600092      PMCID： PMC7446559          DOI： 10.1177/0271678X20938146

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  10 in total

1.  PDGFR-β restores blood-brain barrier functions in a mouse model of focal cerebral ischemia.

Authors:  Jie Shen; Guihua Xu; Runxiu Zhu; Jun Yuan; Yoko Ishii; Takeru Hamashima; Takako Matsushima; Seiji Yamamoto; Yusuke Takatsuru; Junichi Nabekura; Masakiyo Sasahara
Journal:  J Cereb Blood Flow Metab       Date:  2018-04-09       Impact factor: 6.200

2.  Higher prevalence of cerebral white matter hyperintensities in homozygous APOE-ɛ4 allele carriers aged 45-75: Results from the ALFA study.

Authors:  Santiago Rojas; Anna Brugulat-Serrat; Nuria Bargalló; Carolina Minguillón; Alan Tucholka; Carles Falcon; Andreia Carvalho; Sebastian Morán; Manel Esteller; Nina Gramunt; Karine Fauria; Jordi Camí; José L Molinuevo; Juan D Gispert
Journal:  J Cereb Blood Flow Metab       Date:  2017-05-11       Impact factor: 6.200

3.  Annexin A2 is a Robo4 ligand that modulates ARF6 activation-associated cerebral trans-endothelial permeability.

Authors:  Wenlu Li; Zhigang Chen; Jing Yuan; Zhanyang Yu; Chongjie Cheng; Qiuchen Zhao; Lena Huang; Katherine A Hajjar; Zhong Chen; Eng H Lo; Haibin Dai; Xiaoying Wang
Journal:  J Cereb Blood Flow Metab       Date:  2018-05-22       Impact factor: 6.200

4.  Apolipoprotein E4 Expression Causes Gain of Toxic Function in Isogenic Human Induced Pluripotent Stem Cell-Derived Endothelial Cells.

Authors:  Claus Rieker; Eugenia Migliavacca; Angélique Vaucher; Gilles Baud; Julien Marquis; Aline Charpagne; Nagabhooshan Hegde; Laurence Guignard; Michael McLachlan; Amy M Pooler
Journal:  Arterioscler Thromb Vasc Biol       Date:  2019-07-18       Impact factor: 8.311

5.  Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury.

Authors:  Yoon Kyung Choi; Takakuni Maki; Emiri T Mandeville; Seong-Ho Koh; Kazuhide Hayakawa; Ken Arai; Young-Myeong Kim; Michael J Whalen; Changhong Xing; Xiaoying Wang; Kyu-Won Kim; Eng H Lo
Journal:  Nat Med       Date:  2016-09-26       Impact factor: 53.440

6.  Acute pain alters P-glycoprotein-containing protein complexes in rat cerebral microvessels: Implications for P-glycoprotein trafficking.

Authors:  Margaret E Tome; Chelsea K Jarvis; Charles P Schaefer; Leigh M Jacobs; Joseph M Herndon; Kristen C Hunn; Nathan B Arkwright; Kathryn L Kellohen; Peyton C Mierau; Thomas P Davis
Journal:  J Cereb Blood Flow Metab       Date:  2018-10-22       Impact factor: 6.200

7.  Blood-brain barrier breakdown in the aging human hippocampus.

Authors:  Axel Montagne; Samuel R Barnes; Melanie D Sweeney; Matthew R Halliday; Abhay P Sagare; Zhen Zhao; Arthur W Toga; Russell E Jacobs; Collin Y Liu; Lilyana Amezcua; Michael G Harrington; Helena C Chui; Meng Law; Berislav V Zlokovic
Journal:  Neuron       Date:  2015-01-21       Impact factor: 17.173

8.  APOEɛ4 Gene Dose and Sex Effects on Alzheimer's Disease MRI Biomarkers in Older Adults with Mild Cognitive Impairment.

Authors:  Zachary Hobel; A Lisette Isenberg; Dhvani Raghupathy; Wendy Mack; Judy Pa
Journal:  J Alzheimers Dis       Date:  2019       Impact factor: 4.472

9.  Differing associations between Aβ accumulation, hypoperfusion, blood-brain barrier dysfunction and loss of PDGFRB pericyte marker in the precuneus and parietal white matter in Alzheimer's disease.

Authors:  J Scott Miners; Isabel Schulz; Seth Love
Journal:  J Cereb Blood Flow Metab       Date:  2017-02-02       Impact factor: 6.200

10.  APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline.

Authors:  Axel Montagne; Daniel A Nation; Abhay P Sagare; Giuseppe Barisano; Melanie D Sweeney; Ararat Chakhoyan; Maricarmen Pachicano; Elizabeth Joe; Amy R Nelson; Lina M D'Orazio; David P Buennagel; Michael G Harrington; Tammie L S Benzinger; Anne M Fagan; John M Ringman; Lon S Schneider; John C Morris; Eric M Reiman; Richard J Caselli; Helena C Chui; Julia Tcw; Yining Chen; Judy Pa; Peter S Conti; Meng Law; Arthur W Toga; Berislav V Zlokovic
Journal:  Nature       Date:  2020-04-29       Impact factor: 49.962
  10 in total
  4 in total

1.  Postoperative delirium and changes in the blood-brain barrier, neuroinflammation, and cerebrospinal fluid lactate: a prospective cohort study.

Authors:  Jennifer Taylor; Margaret Parker; Cameron P Casey; Sean Tanabe; David Kunkel; Cameron Rivera; Henrik Zetterberg; Kaj Blennow; Robert A Pearce; Richard C Lennertz; Robert D Sanders
Journal:  Br J Anaesth       Date:  2022-02-08       Impact factor: 11.719

Review 2.  A new perspective on cerebrospinal fluid dynamics after subarachnoid hemorrhage: From normal physiology to pathophysiological changes.

Authors:  Yuanjian Fang; Lei Huang; Xiaoyu Wang; Xiaoli Si; Cameron Lenahan; Hui Shi; Anwen Shao; Jiping Tang; Sheng Chen; Jianmin Zhang; John H Zhang
Journal:  J Cereb Blood Flow Metab       Date:  2021-11-22       Impact factor: 6.960

Review 3.  Lipocalin 2 regulates iron homeostasis, neuroinflammation, and insulin resistance in the brains of patients with dementia: Evidence from the current literature.

Authors:  Daejin Lim; Jae-Ho Jeong; Juhyun Song
Journal:  CNS Neurosci Ther       Date:  2021-05-04       Impact factor: 5.243

4.  Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study.

Authors:  Maria-Eleni Dounavi; Audrey Low; Elizabeth F McKiernan; Elijah Mak; Graciela Muniz-Terrera; Karen Ritchie; Craig W Ritchie; Li Su; John T O'Brien
Journal:  J Cereb Blood Flow Metab       Date:  2021-06-02       Impact factor: 6.200
  4 in total

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