Giuseppe G Caprio1, Desiree Picascia1, Marcello Dallio1, Pietro P Vitiello1, Emilio F Giunta1, Vincenzo De Falco1, Ludovico Abenavoli2, Anna C Procopio2, Vincenzo Famiglietti1, Erika Martinelli1, Antonietta G Gravina1, Alessandro Federico1, Fortunato Ciardiello1, Carmelina Loguercio1, Davide Ciardiello1.
Abstract
BACKGROUND: In accordance with the scientific literature heavy alcohol consumption (>50g per day) represents a risk factor for several diseases development, including cancer. However, the oncogenic role of light alcohol drinking (<12.5g per day) is still unknown.
OBJECTIVE: To assess the scientific knowledge about light alcohol consumption and the risk of malignancy onset.
METHODS: To collect the scientific evidences regarding this topic the keywords "light alcohol drinking", "light alcohol consumption" and "cancer", were used. Papers published during the last 15 years were analyzed, in order to select the most recent evidence. Meta-analyses with well-defined levels of alcohol intake were included in the present review. Other studies that focused on biochemical, molecular and genetic aspects, as well as duplicate articles, were excluded.
RESULTS: Twenty-nine large, meta-analyses were included in this review. Light alcohol drinking was not associated with an increased risk of cancer occurrence, with the exception of breast and prostate cancer and melanoma. Furthermore, a possible protective role of light alcohol consumption on the development of bladder, kidney and ovarian cancer and Non Hodgkin Lymphoma was observed.
CONCLUSION: Light alcohol drinking was not associated with the development of several malignancies, except for a light increase of melanoma, breast cancer in women and prostate cancer in men. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
BACKGROUND: In accordance with the scientific literature heavy alcohol consumption (>50g per day) represents a risk factor for several diseases development, including cancer. However, the oncogenic role of light alcohol drinking (<12.5g per day) is still unknown.
OBJECTIVE: To assess the scientific knowledge about light alcohol consumption and the risk of malignancy onset.
METHODS: To collect the scientific evidences regarding this topic the keywords "light alcohol drinking", "light alcohol consumption" and "cancer", were used. Papers published during the last 15 years were analyzed, in order to select the most recent evidence. Meta-analyses with well-defined levels of alcohol intake were included in the present review. Other studies that focused on biochemical, molecular and genetic aspects, as well as duplicate articles, were excluded.
RESULTS: Twenty-nine large, meta-analyses were included in this review. Light alcohol drinking was not associated with an increased risk of cancer occurrence, with the exception of breast and prostate cancer and melanoma. Furthermore, a possible protective role of light alcohol consumption on the development of bladder, kidney and ovarian cancer and Non Hodgkin Lymphoma was observed.
CONCLUSION: Light alcohol drinking was not associated with the development of several malignancies, except for a light increase of melanoma, breast cancer in women and prostate cancer in men. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Entities:
Keywords:
Alcohol consumption; cancer; cancer epidemiology; carcinogenesis; cell biology; public health
Year: 2020
PMID： 32598271 DOI： 10.2174/1574887115666200628143015
Source DB: PubMed Journal: Rev Recent Clin Trials ISSN： 1574-8871