| Literature DB >> 3259742 |
R E Heikkila1, S K Youngster, D U Panek, A Giovanni, P K Sonsalla.
Abstract
The nigrostriatal dopaminergic neurotoxicity of MPTP was prevented in mice in a dose-dependent manner by the monoamine oxidase-B (MAO-B) inhibitor deprenyl. This finding, combined with other observations, points out the important role of MAO-B in the bioactivation of MPTP. In the present study, some comparisons between MPTP and several of its structural analogs will be presented.Entities:
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Year: 1988 PMID： 3259742 DOI： 10.1016/0300-483x(88)90035-2
Source DB: PubMed Journal: Toxicology ISSN： 0300-483X Impact factor: 4.221