Literature DB >> 3259727

Cachectin/TNF and IL-1 induced by glucose-modified proteins: role in normal tissue remodeling.

H Vlassara1, M Brownlee, K R Manogue, C A Dinarello, A Pasagian.   

Abstract

Proteins undergo a series of nonenzymatic reactions with glucose over time to form advanced glycosylation end products (AGEs). Macrophages have a receptor that recognizes the AGE moiety and mediates the uptake and degradation of AGE proteins. This removal process is associated with the production and secretion of cachectin (tumor necrosis factor) and interleukin-1, two cytokines with diverse and seemingly paradoxical biological activities. The localized release and action of these cytokines could account for the coordinated removal and replacement of senescent extracellular matrix components in normal tissue homeostasis.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 3259727     DOI： 10.1126/science.3259727

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  107 in total

Review 1.  Autocrine and paracrine mechanisms in the early stages of diabetic nephropathy.

Authors:  G Pugliese; F Pricci; G Romeo; G Leto; L Amadio; C Iacobini; U Di Mario
Journal:  J Endocrinol Invest       Date:  1999-10       Impact factor: 4.256

Review 2.  [Non-enzymatic glycation and oxidative stress in chronic illnesses and diabetes mellitus].

Authors:  P P Nawroth; A Bierhaus; G E Vogel; M A Hofmann; M Zumbach; P Wahl; R Ziegler
Journal:  Med Klin (Munich)       Date:  1999-01-15

3.  A previously undescribed chemical link between smoking and metabolic disease.

Authors:  Tobin J Dickerson; Kim D Janda
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-28       Impact factor: 11.205

Review 4.  Trends in advanced glycation end products research in diabetes mellitus and its complications.

Authors:  José D Méndez; Jianling Xie; Montserrat Aguilar-Hernández; Verna Méndez-Valenzuela
Journal:  Mol Cell Biochem       Date:  2010-03-23       Impact factor: 3.396

5.  Elevated AGE-modified ApoB in sera of euglycemic, normolipidemic patients with atherosclerosis: relationship to tissue AGEs.

Authors:  A W Stitt; C He; S Friedman; L Scher; P Rossi; L Ong; H Founds; Y M Li; R Bucala; H Vlassara
Journal:  Mol Med       Date:  1997-09       Impact factor: 6.354

6.  Vascular endothelial growth factor C promotes survival of retinal vascular endothelial cells via vascular endothelial growth factor receptor-2.

Authors:  Bojun Zhao; Gill Smith; Jun Cai; Aihua Ma; Mike Boulton
Journal:  Br J Ophthalmol       Date:  2006-08-30       Impact factor: 4.638

7.  Macrophage/monocyte receptor for nonenzymatically glycosylated protein is upregulated by cachectin/tumor necrosis factor.

Authors:  H Vlassara; L Moldawer; B Chan
Journal:  J Clin Invest       Date:  1989-12       Impact factor: 14.808

8.  Phosphorylation of pleckstrin increases proinflammatory cytokine secretion by mononuclear phagocytes in diabetes mellitus.

Authors:  Yong Ding; Alpdogan Kantarci; John A Badwey; Hatice Hasturk; Alan Malabanan; Thomas E Van Dyke
Journal:  J Immunol       Date:  2007-07-01       Impact factor: 5.422

Review 9.  Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy.

Authors:  Ralph D Sanderson; Michael Elkin; Alan C Rapraeger; Neta Ilan; Israel Vlodavsky
Journal:  FEBS J       Date:  2016-11-16       Impact factor: 5.542

10.  Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.

Authors:  A M Schmidt; O Hori; J X Chen; J F Li; J Crandall; J Zhang; R Cao; S D Yan; J Brett; D Stern
Journal:  J Clin Invest       Date:  1995-09       Impact factor: 14.808
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.