Literature DB >> 32595132

Optic nerve invasion of non-juxtapapillary uveal melanoma: a rare occurrence.

Abhimanyu Sharma1, Dilip K Mishra2, Swathi Kaliki3.   

Abstract

A 44-year-old man presented with complaints of pain and discomfort in his left eye (OS). On examination, he had bare perception of light in OS and had a diffuse pigmented mass lesion in the nasal quadrant of the bulbar conjunctiva, associated with neovascularisation of the iris and iridocyclitis, with no fundus view. Intraocular pressure OS was 40 mm Hg. B-scan ultrasonography OS revealed an intraocular mass with thickened sclerochoroidal complex. A clinical diagnosis of OS ciliochoroidal melanoma with extraocular extension was made. He underwent OS extended enucleation with implant. Histopathological examination confirmed the diagnosis of ciliochoroidal melanoma with tumour extension into the optic nerve posteriorly and the extrascleral tissues anteriorly. There was no evidence of systemic metastasis. Even in a case of non-juxtapapillary uveal melanoma, poor vision and high intraocular pressure are clinical indicators of optic nerve tumour invasion. © BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.

Entities:  

Keywords:  macula; ophthalmology; pathology

Mesh:

Year:  2020        PMID: 32595132      PMCID: PMC7322335          DOI: 10.1136/bcr-2020-234610

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  21 in total

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Authors:  W H Spencer
Journal:  Am J Ophthalmol       Date:  1975-09       Impact factor: 5.258

2.  Malignant melanoma of the choroid and ciliary body; a study of 2,535 cases.

Authors:  H C WILDER; E V PAUL
Journal:  Mil Surg       Date:  1951-10

3.  Optic nerve invasion of uveal melanoma: clinical characteristics and metastatic pattern.

Authors:  Jens Lindegaard; Peter Isager; Jan Ulrik Prause; Steffen Heegaard
Journal:  Invest Ophthalmol Vis Sci       Date:  2006-08       Impact factor: 4.799

4.  Histopathologically verified non-vascular optic nerve lesions in Denmark 1940-99.

Authors:  Jens Lindegaard; Steffen Heegaard; Jan Ulrik Prause
Journal:  Acta Ophthalmol Scand       Date:  2002-02

5.  Ciliary body melanoma with optic nerve invasion.

Authors:  S al-Haddab; A Hidayat; K F Tabbara
Journal:  Br J Ophthalmol       Date:  1990-02       Impact factor: 4.638

6.  Incidence of noncutaneous melanomas in the U.S.

Authors:  Colleen C McLaughlin; Xiao-Cheng Wu; Ahmedin Jemal; Howard J Martin; Lisa M Roche; Vivien W Chen
Journal:  Cancer       Date:  2005-03-01       Impact factor: 6.860

7.  Uveal melanoma: case report of extension through the optic nerve to the surgical margin in the orbital apex.

Authors:  J Chess; D M Albert; A R Bellows; R Dallow
Journal:  Br J Ophthalmol       Date:  1984-04       Impact factor: 4.638

8.  Assessment of metastatic disease status at death in 435 patients with large choroidal melanoma in the Collaborative Ocular Melanoma Study (COMS): COMS report no. 15.

Authors: 
Journal:  Arch Ophthalmol       Date:  2001-05

9.  Prevalence and mechanisms of secondary intraocular pressure elevation in eyes with intraocular tumors.

Authors:  C L Shields; J A Shields; M B Shields; J J Augsburger
Journal:  Ophthalmology       Date:  1987-07       Impact factor: 12.079

10.  Mechanisms of Optic Nerve Invasion in Primary Choroidal Melanoma.

Authors:  Eszter Szalai; Jill R Wells; Hans E Grossniklaus
Journal:  Ocul Oncol Pathol       Date:  2017-04-05
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