Julie Loebach Wetherell1,2, Hayley S Ripperger3, Michelle Voegtle3, Beau M Ances4, David Balota5, Emily S Bower2, Colin Depp1,2, Lisa Eyler2, Erin R Foster3,4,6, Denise Head5,7, Tamara Hershey3,7, Steven Hickman2, Noralinda Kamantigue2, Samuel Klein8, J Philip Miller9, Michael D Yingling3, Jeanne Nichols2, Ginger E Nicol3, Bruce W Patterson8, Thomas L Rodebaugh5, Joshua S Shimony7, Abraham Snyder7, Mary Stephens3, Susan Tate2, Mary L Uhrich3,10, David Wing2, Gregory F Wu4,11, Eric J Lenze3. 1. VA San Diego Healthcare System, San Diego, CA, USA. 2. University of California San Diego, San Diego, CA, USA. 3. Department of Psychiatry, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA. 4. Department of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA. 5. Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA. 6. Program in Occupational Therapy, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA. 7. Mallinckrodt Institute of Radiology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA. 8. Center for Human Nutrition, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA. 9. Division of Biostatistics, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA. 10. Program in Physical Therapy, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA. 11. Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Abstract
BACKGROUND/AIMS: Age-related cognitive decline is a pervasive problem in our aging population. To date, no pharmacological treatments to halt or reverse cognitive decline are available. Behavioral interventions, such as physical exercise and Mindfulness-Based Stress Reduction, may reduce or reverse cognitive decline, but rigorously designed randomized controlled trials are needed to test the efficacy of such interventions. METHODS: Here, we describe the design of the Mindfulness, Education, and Exercise study, an 18-month randomized controlled trial that will assess the effect of two interventions-mindfulness training plus moderate-to-vigorous intensity exercise or moderate-to-vigorous intensity exercise alone-compared with a health education control group on cognitive function in older adults. An extensive battery of biobehavioral assessments will be used to understand the mechanisms of cognitive remediation, by using structural and resting state functional magnetic resonance imaging, insulin sensitivity, inflammation, and metabolic and behavioral assessments. RESULTS: We provide the results from a preliminary study (n = 29) of non-randomized pilot participants who received both the exercise and Mindfulness-Based Stress Reduction interventions. We also provide details on the recruitment and baseline characteristics of the randomized controlled trial sample (n = 585). CONCLUSION: When complete, the Mindfulness, Education, and Exercise study will inform the research community on the efficacy of these widely available interventions improve cognitive functioning in older adults.
RCT Entities:
BACKGROUND/AIMS: Age-related cognitive decline is a pervasive problem in our aging population. To date, no pharmacological treatments to halt or reverse cognitive decline are available. Behavioral interventions, such as physical exercise and Mindfulness-Based Stress Reduction, may reduce or reverse cognitive decline, but rigorously designed randomized controlled trials are needed to test the efficacy of such interventions. METHODS: Here, we describe the design of the Mindfulness, Education, and Exercise study, an 18-month randomized controlled trial that will assess the effect of two interventions-mindfulness training plus moderate-to-vigorous intensity exercise or moderate-to-vigorous intensity exercise alone-compared with a health education control group on cognitive function in older adults. An extensive battery of biobehavioral assessments will be used to understand the mechanisms of cognitive remediation, by using structural and resting state functional magnetic resonance imaging, insulin sensitivity, inflammation, and metabolic and behavioral assessments. RESULTS: We provide the results from a preliminary study (n = 29) of non-randomized pilot participants who received both the exercise and Mindfulness-Based Stress Reduction interventions. We also provide details on the recruitment and baseline characteristics of the randomized controlled trial sample (n = 585). CONCLUSION: When complete, the Mindfulness, Education, and Exercise study will inform the research community on the efficacy of these widely available interventions improve cognitive functioning in older adults.
Entities:
Keywords:
Meditation; aerobic exercise; aging; elderly; intervention study
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