| Literature DB >> 32593967 |
Piotr Okińczyc1, Emil Paluch2, Roman Franiczek2, Jarosław Widelski3, Krzysztof Kamil Wojtanowski3, Tomasz Mroczek4, Barbara Krzyżanowska2, Krystyna Skalicka-Woźniak4, Zbigniew Sroka5.
Abstract
In this study, we evaluated antimicrobial activity, antimicrobial activity in combination with antibiotics, and chemical composition of Nepalese propolis 70% ethanolic extracts. Propolis originated from two genera of bees - Apis mellifera L. and Trigona sp. HPLC-DAD-MS/MS analyses revealed that the composition of both extracts was almost the same and the main components were flavonoid aglycones (mainly neoflavonoids, isoflavonoids) and pterocarpans. The highest antibacterial activity (disc diffusion test) was observed against Helicobacter pylori, Staphylococcus aureus and Shigella flexneri. Antibiotics exhibited synergism with Apis mellifera L. and Trigona sp. propolis against S. aureus and the strongest effect was observed for the combination with amikacin and tetracycline. Moreover, Nepalase propolis inhibited filamentation of C. albicans and caused oxidative stress by production of the superoxide anion radical (O2-) and a lower concentration of the hydroxyl radical (OH). Propolis extracts are potent antibacterial agents and may be used in combination with antibiotics.Entities:
Keywords: Antibacterial and antifungal activity; Antibiotics; Dereplication; Nepal; Propolis
Year: 2020 PMID： 32593967 DOI： 10.1016/j.biopha.2020.110435
Source DB: PubMed Journal: Biomed Pharmacother ISSN： 0753-3322 Impact factor: 6.529