Da Hea Seo1, Yong-Ho Lee2, Young Ju Suh3, Seong Hee Ahn1, Seongbin Hong1, Young Ju Choi4, Byoung Wook Huh4, Seok Won Park2, Eunjig Lee2, So Hun Kim5. 1. Department of Endocrinology and Metabolism, Inha University School of Medicine, Incheon, Republic of Korea. 2. Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. 3. Department of Biomedical Sciences, Inha University School of Medicine, Incheon, Republic of Korea. 4. Huh's Diabetes Center, Seoul, Republic of Korea. 5. Department of Endocrinology and Metabolism, Inha University School of Medicine, Incheon, Republic of Korea. Electronic address: shoney@inha.ac.kr.
Abstract
BACKGROUND AND AIMS: Sarcopenia leads to metabolic and vascular abnormalities. However, little is known regarding the independent relationship between skeletal muscle mass and atherosclerosis in patients with type 2 diabetes mellitus (T2DM). This study aimed to evaluate the association between skeletal muscle mass and carotid atherosclerosis in men and women with T2DM. METHODS: In this cross-sectional study, a total of 8202 patients with T2DM were recruited from the Seoul Metabolic Syndrome cohort. Skeletal muscle mass was estimated using bioimpedance analysis, while skeletal muscle mass index (SMI, %) was defined as total skeletal muscle mass (kg)/body weight (kg) × 100. Both carotid arteries were examined by B-mode ultrasound. Carotid atherosclerosis was defined by having a carotid plaque or mean carotid intima-media thickness (IMT) ≥1.1 mm. RESULTS: Among the entire population, 4299 (52.4%) subjects had carotid atherosclerosis. The prevalence of carotid atherosclerosis increased with decreasing SMI quartiles for both sexes. The odds ratios for carotid atherosclerosis were 2.33 (95% confidence interval [CI], 1.17-4.63) and 2.24 (95% CI, 1.06-4.741) in the lowest versus highest SMI quartile in men and women, respectively, after the adjustment for clinical risk factors. In men, the risk of atherosclerosis increased linearly with decreasing SMI quartiles (p for trend = 0.036). CONCLUSIONS: Low skeletal muscle mass was independently associated with the presence of carotid atherosclerosis in men and women with T2DM.
BACKGROUND AND AIMS: Sarcopenia leads to metabolic and vascular abnormalities. However, little is known regarding the independent relationship between skeletal muscle mass and atherosclerosis in patients with type 2 diabetes mellitus (T2DM). This study aimed to evaluate the association between skeletal muscle mass and carotid atherosclerosis in men and women with T2DM. METHODS: In this cross-sectional study, a total of 8202 patients with T2DM were recruited from the Seoul Metabolic Syndrome cohort. Skeletal muscle mass was estimated using bioimpedance analysis, while skeletal muscle mass index (SMI, %) was defined as total skeletal muscle mass (kg)/body weight (kg) × 100. Both carotid arteries were examined by B-mode ultrasound. Carotid atherosclerosis was defined by having a carotid plaque or mean carotid intima-media thickness (IMT) ≥1.1 mm. RESULTS: Among the entire population, 4299 (52.4%) subjects had carotid atherosclerosis. The prevalence of carotid atherosclerosis increased with decreasing SMI quartiles for both sexes. The odds ratios for carotid atherosclerosis were 2.33 (95% confidence interval [CI], 1.17-4.63) and 2.24 (95% CI, 1.06-4.741) in the lowest versus highest SMI quartile in men and women, respectively, after the adjustment for clinical risk factors. In men, the risk of atherosclerosis increased linearly with decreasing SMI quartiles (p for trend = 0.036). CONCLUSIONS: Low skeletal muscle mass was independently associated with the presence of carotid atherosclerosis in men and women with T2DM.
Authors: Su Hwan Kim; Hyoun Woo Kang; Ji Bong Jeong; Dong Seok Lee; Dong-Won Ahn; Ji Won Kim; Byeong Gwan Kim; Kook Lae Lee; Sohee Oh; Soon Ho Yoon; Sang Joon Park Journal: PLoS One Date: 2021-08-17 Impact factor: 3.240
Authors: Su Hwan Kim; Ji Bong Jeong; Jinwoo Kang; Dong-Won Ahn; Ji Won Kim; Byeong Gwan Kim; Kook Lae Lee; Sohee Oh; Soon Ho Yoon; Sang Joon Park; Doo Hee Lee Journal: PLoS One Date: 2021-03-19 Impact factor: 3.240
Authors: Vadim V Klimontov; Elena A Koroleva; Rustam S Khapaev; Anton I Korbut; Alexander P Lykov Journal: J Clin Med Date: 2021-12-24 Impact factor: 4.241