Asier Mañas1,2, Borja Del Pozo-Cruz3, Irene Rodríguez-Gómez1,2, José Losa-Reyna1,2,4, Pedro B Júdice5, Luís B Sardinha5, Leocadio Rodríguez-Mañas2,6, Francisco J García-García2,4, Ignacio Ara1,2. 1. GENUD Toledo Research Group, University of Castilla-La Mancha, Spain. 2. CIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain. 3. Motivation and Behaviour Research Program, Institute for Positive Psychology and Education, Faculty of Health Sciences, Australian Catholic University, Sydney, Australia. 4. Geriatric Department, Hospital Virgen del Valle, Toledo, Spain. 5. Exercise and Health Laboratory, CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Portugal. 6. Geriatric Department, Hospital Universitario de Getafe, Spain.
Abstract
BACKGROUND: Cross-sectional evidence exists on the beneficial effects of breaks in sedentary time (BST) on frailty in older adults. Nonetheless, the longitudinal nature of these associations is unknown. This study aimed to investigate the direction and temporal order of the association between accelerometer-derived BST and frailty over time in older adults. METHODS: This longitudinal study analyzed a total of 186 older adults aged 67-90 (76.7 ± 3.9 years; 52.7% females) from the Toledo Study for Healthy Aging over a 4-year period. Number of daily BST was measured by accelerometry. Frailty was assessed with the Frailty Trait Scale. Multiple cross-lagged panel models were used to test the temporal and reciprocal relationship between BST and frailty. RESULTS: For those physically inactive (n = 126), our analyses revealed a reciprocal inverse relationship between BST and frailty, such as higher initial BST predicted lower levels of later frailty (standardized regression coefficient [β] = -0.150, 95% confidence interval [CI] = -0.281, -0.018; p < .05); as well as initial lower frailty levels predicted higher future BST (β = -0.161, 95% CI = -0.310, -0.011; p < .05). Conversely, no significant pathway was found in the active participants (n = 60). CONCLUSIONS: In physically inactive older adults, the relationship between BST and frailty is bidirectional, while in active individuals no associations were found. This investigation provides preliminary longitudinal evidence that breaking-up sedentary time more often reduces frailty in those older adults who do not meet physical activity recommendations. Targeting frequent BST may bring a feasible approach to decrease the burden of frailty among more at-risk inactive older adults.
BACKGROUND: Cross-sectional evidence exists on the beneficial effects of breaks in sedentary time (BST) on frailty in older adults. Nonetheless, the longitudinal nature of these associations is unknown. This study aimed to investigate the direction and temporal order of the association between accelerometer-derived BST and frailty over time in older adults. METHODS: This longitudinal study analyzed a total of 186 older adults aged 67-90 (76.7 ± 3.9 years; 52.7% females) from the Toledo Study for Healthy Aging over a 4-year period. Number of daily BST was measured by accelerometry. Frailty was assessed with the Frailty Trait Scale. Multiple cross-lagged panel models were used to test the temporal and reciprocal relationship between BST and frailty. RESULTS: For those physically inactive (n = 126), our analyses revealed a reciprocal inverse relationship between BST and frailty, such as higher initial BST predicted lower levels of later frailty (standardized regression coefficient [β] = -0.150, 95% confidence interval [CI] = -0.281, -0.018; p < .05); as well as initial lower frailty levels predicted higher future BST (β = -0.161, 95% CI = -0.310, -0.011; p < .05). Conversely, no significant pathway was found in the active participants (n = 60). CONCLUSIONS: In physically inactive older adults, the relationship between BST and frailty is bidirectional, while in active individuals no associations were found. This investigation provides preliminary longitudinal evidence that breaking-up sedentary time more often reduces frailty in those older adults who do not meet physical activity recommendations. Targeting frequent BST may bring a feasible approach to decrease the burden of frailty among more at-risk inactive older adults.
Authors: Ana Moradell; Irene Rodríguez-Gómez; Ángel Iván Fernández-García; David Navarrete-Villanueva; Jorge Marín-Puyalto; Jorge Pérez-Gómez; José Gerardo Villa-Vicente; Marcela González-Gross; Ignacio Ara; José Antonio Casajús; Alba Gómez-Cabello; Germán Vicente-Rodríguez Journal: Int J Environ Res Public Health Date: 2021-04-03 Impact factor: 3.390
Authors: Ángel I Fernández-García; Jorge Marin-Puyalto; Alba Gómez-Cabello; Ángel Matute-Llorente; Jorge Subías-Perié; Jorge Pérez-Gómez; Gabriel Lozano-Berges; Asier Mañas; Amelia Guadalupe-Grau; Marcela González-Gross; Ignacio Ara; José A Casajús; Germán Vicente-Rodríguez Journal: Biomed Res Int Date: 2021-05-31 Impact factor: 3.411