| Literature DB >> 32591324 |
Akihiro Kaneko1, Tetsuya Matsumoto2, Hiroshi Iwabuchi3, Junko Sato2, Tomotaro Wakamura2, Hiroshi Kiyota2, Kazuhiro Tateda2, Hideaki Hanaki4, Noriyuki Sakakibara5, Takayuki Mizuno5, Hisashi Miyajima6, Hiroyuki Naito7, Ritsuo Takagi8, Yasumitsu Kodama8, Akira Yamaguchi9, Ryo Akasiba9, Nobuo Yamane10, Yoshinori Jinbu11, Mikio Kusama11, Norito Miyagi12, Reiko Kato13, Noriko Nakatogawa14, Kazumi Izawa15, Hideki Tanzawa16, Yoshinao Kozu16, Hideki Watanabe17, Koichi Matsumoto17, Takahiko Shibahara18, Yasunobu Busujima19, Tsuyoshi Takato20, Haruo Sakamoto21, Daisuke Watanabe22, Hiroyuki Kubota22, Jiro Sasaki23, Masataka Uematsu24, Masashi Sasaki25, Atsuo Kaetsu26, Fumitaka Terasawa26, Yoshiaki Yura27, Soichi Iwai27, Shosuke Morita28, Kazuhiro Matsumoto28, Tetsuo Oonishi29, Takahide Komori30, Shungo Furudoi30, Junko Fujibayashi31, Masahiro Urade32, Hiromitsu Kishimoto32, Takashi Yoshii33, Takefumi Morihana34, Daisuke Miyai35, Tetsuji Okamoto36, Taku Kanda36, Kosei Okamoto37, Akihiko Sakamoto38, Yoshiro Matsui39, Minoru Miyake39, Takashi Sawai39, Tetsuro Ikebe40, Kenichiro Hashimoto40.
Abstract
We report on the findings of the first antimicrobial susceptibility surveillance study in Japan of isolates recovered from odontogenic infections. Of the 38 facilities where patients representing the 4 groups of odontogenic infections were seen, 102 samples were collected from cases of periodontitis (group 1), 6 samples from pericoronitis (group 2), 84 samples from jaw inflammation (group 3) and 54 samples from phlegmon of the jaw bone area (group 4) for a total of 246 samples. The positivity rates of bacterial growth on culture were 85.3%, 100%, 84% and 88.9%, respectively, for groups 1, 2, 3 and 4. Streptococcus spp. isolation rates according to odontogenic infection group were 22% (group 1), 17.7% (group 3) and 20.7% (group 4). Anaerobic isolation rates were 66.9% (group 1), 71.8% (group 3) and 68.2% (group 4). Drug susceptibility tests were performed on 726 strains excluding 121 strains that were undergrown. The breakdown of the strains subjected to testing was 186 Streptococcus spp., 179 anaerobic gram-positive cocci, 246 Prevotella spp., 27 Porphyromonas spp., and 88 Fusobacterium spp. The isolates were tested against 30 antimicrobial agents. Sensitivities to penicillins and cephems were good except for Prevotella spp. The low sensitivities of Prevotella spp is due to β-lactamase production. Prevotella strains resistant to macrolides, quinolones, and clindamycin were found. No strains resistant to carbapenems or penems were found among all strains tested. No anaerobic bacterial strain was resistant to metronidazole. Antimicrobial susceptibility testing performed on the S. anginosus group and anaerobic bacteria, which are the major pathogens associated with odontogenic infections, showed low MIC90 values to the penicillins which are the first-line antimicrobial agents for odontogenic infections; however, for Prevotella spp., penicillins combined with β-lactamase inhibitor showed low MIC90 values.Entities:
Keywords: Drug Resistance; Odontogenic infection; Surveillance; Susceptibility
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Year: 2020 PMID： 32591324 DOI： 10.1016/j.jiac.2020.05.019
Source DB: PubMed Journal: J Infect Chemother ISSN： 1341-321X Impact factor: 2.211