| Literature DB >> 32589111 |
Danielle K Tarbert1,2,3,4,5, Lisa L Bolin1,2,3,4,5, Alison E Stout1,2,3,4,5, Deanna M W Schaefer1,2,3,4,5, Rebecca E Ruby1,2,3,4,5, Julia Rodriguez-Ramos Fernandez1,2,3,4,5, Gerald E Duhamel1,2,3,4,5, Gary R Whittaker1,2,3,4,5, Ricardo de Matos1,2,3,4,5.
Abstract
Ferret systemic coronaviral disease (FSCD) is a well-established cause of mortality in domestic ferrets. We describe herein novel findings in a case of FSCD that was diagnosed and medically managed following virus detection by immunohistochemical (IHC) staining of surgical biopsy samples. Hematologic changes in this ferret suggested spread of the virus to the bone marrow, which was confirmed by IHC staining of a postmortem sample. Genotyping of the virus indicated that the virus grouped with alphacoronaviruses and was most closely related to ferret enteric coronavirus (FRECV) MSU-2. Our clinical case demonstrates that a FRECV MSU-2-like ferret coronavirus associated previously with the enteric pathotype may cause systemic disease, including bone marrow involvement causing persistent pancytopenia.Entities:
Keywords: Mustela putorius furo; alphacoronavirus; bone marrow; ferret coronavirus MSU-2
Mesh：
Year: 2020 PMID： 32589111 PMCID： PMC7438646 DOI： 10.1177/1040638720937105
Source DB: PubMed Journal: J Vet Diagn Invest ISSN： 1040-6387 Impact factor: 1.279