Youxiang Jin1, Jiaoyang Wu1, Zhiyang Lin1, Yun Lan1, Chuan Wang1,2. 1. Hefei National Laboratory for Physical Science at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China. 2. Center for Excellence in Molecular Synthesis of CAS, Hefei, Anhui 230026, P. R. China.
Abstract
Herein we successfully applied Katritzky salts as the alkyl electrophile in the reductive allylic defluorinative cross-coupling reaction with α-trifluoromethyl alkenes. The merger of C-F and C-N bond cleavage via the synergistic effect of nickel and zinc allows the efficient synthesis of diverse gem-difluoroalkenes with a good tolerance for various functional groups.
Herein we successfully applied Katritzky salts as the alkyl electrophile in the reductive allylic defluorinative cross-coupling reaction with α-trifluoromethyl alkenes. The merger of n class="Chemical">C-F and C-N bond cleavage via the synergistic effect of nickel and zinc allows the efficient synthesis of diverse gem-difluoroalkenes with a good tolerance for various functional groups.