A Mantovani1, E Danese2, G L Salvagno2, M Gelati2, T Turino3, C Bovo4, G Lippi2, G Targher3. 1. Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale Stefani, 1, 37126, Verona, Italy. alessandro.mantovani@univr.it. 2. Section of Clinical Biochemistry, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy. 3. Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale Stefani, 1, 37126, Verona, Italy. 4. Medical Direction, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
Abstract
OBJECTIVE: Previous studies showed a significant association between lower plasma adiponectin levels and higher risk of adverse cardiovascular outcomes in patients with and without type 2 diabetes mellitus (T2DM). Presently, it is uncertain whether lower plasma adiponectin levels are associated with greater plasma thrombin generation in patients with T2DM. PATIENTS AND METHODS: We studied 82 middle-aged men with non-insulin-treated T2DM [mean age ± SD: 64.1 ± 8 years; median duration of diabetes: 12.5 (inter-quartile range 6-19) years; mean hemoglobin A1c 7.0 ± 0.7%], consecutively attending our diabetes outpatient service over a 6-month period. Using the newly developed fully automated thrombin generation analyzer ST Genesia®, we measured the plasma parameters lag time (LT), time to peak (TP), peak height (PH) and endogenous thrombin potential (ETP) in all participants. RESULTS: In univariable linear regression analyses, lower plasma adiponectin levels were significantly associated with higher plasma thrombin generation parameters, as reflected by higher values of PH (Pearson's r coefficient = - 0.228, p = 0.039) and EPT (r = - 0.293, p = 0.007). Plasma adiponectin levels were not significantly associated with other thrombin generation parameters (LT and TP). Notably, the significant associations of plasma adiponectin levels with thrombin PH and EPT values persisted after adjustment for age and adiposity measures, but they were lost after additional adjustment for plasma triglycerides. CONCLUSION: Our findings show for the first time the existence of a significant association between lower levels of plasma adiponectin and greater plasma thrombin generation (as assessed by the ST Genesia® analyzer) in men with non-insulin-treated T2DM, which appears to be largely mediated by plasma triglycerides.
OBJECTIVE: Previous studies showed a significant association between lower plasma adiponectin levels and higher risk of adverse cardiovascular outcomes in patients with and without type 2 diabetes mellitus (T2DM). Presently, it is uncertain whether lower plasma adiponectin levels are associated with greater plasma thrombin generation in patients with T2DM. PATIENTS AND METHODS: We studied 82 middle-aged men with non-insulin-treated T2DM [mean age ± SD: 64.1 ± 8 years; median duration of diabetes: 12.5 (inter-quartile range 6-19) years; mean hemoglobin A1c 7.0 ± 0.7%], consecutively attending our diabetesoutpatient service over a 6-month period. Using the newly developed fully automated thrombin generation analyzer ST Genesia®, we measured the plasma parameters lag time (LT), time to peak (TP), peak height (PH) and endogenous thrombin potential (ETP) in all participants. RESULTS: In univariable linear regression analyses, lower plasma adiponectin levels were significantly associated with higher plasma thrombin generation parameters, as reflected by higher values of PH (Pearson's r coefficient = - 0.228, p = 0.039) and EPT (r = - 0.293, p = 0.007). Plasma adiponectin levels were not significantly associated with other thrombin generation parameters (LT and TP). Notably, the significant associations of plasma adiponectin levels with thrombin PH and EPT values persisted after adjustment for age and adiposity measures, but they were lost after additional adjustment for plasma triglycerides. CONCLUSION: Our findings show for the first time the existence of a significant association between lower levels of plasma adiponectin and greater plasma thrombin generation (as assessed by the ST Genesia® analyzer) in men with non-insulin-treated T2DM, which appears to be largely mediated by plasma triglycerides.
Entities:
Keywords:
Adiponectin; Plasma thrombin generation; Triglycerides; Type 2 diabetes
Authors: Patricia Gomez-Rosas; Marina Pesenti; Cristina Verzeroli; Cinzia Giaccherini; Laura Russo; Roberta Sarmiento; Giovanna Masci; Luigi Celio; Mauro Minelli; Sara Gamba; Carmen Julia Tartari; Carlo Tondini; Francesco Giuliani; Fausto Petrelli; Andrea D'Alessio; Giampietro Gasparini; Roberto Labianca; Armando Santoro; Filippo De Braud; Marina Marchetti; Anna Falanga Journal: TH Open Date: 2021-02-10
Authors: Godfrey S Temba; Nadira Vadaq; Jun Wan; Vesla Kullaya; Dana Huskens; Tal Pecht; Martin Jaeger; Collins K Boahen; Vasiliki Matzaraki; Wieteke Broeders; Leo A B Joosten; Sultana M H Faradz; Gibson Kibiki; Saskia Middeldorp; Duccio Cavalieri; Paolo Lionetti; Philip G de Groot; Joachim L Schultze; Mihai G Netea; Vinod Kumar; Bas de Laat; Blandina T Mmbaga; Andre J van der Ven; Mark Roest; Quirijn de Mast Journal: J Thromb Haemost Date: 2022-02-10 Impact factor: 16.036