Sophie de Visme1, Martin Chalumeau2, Karine Levieux3, Hugues Patural4, Inge Harrewijn5, Elisabeth Briand-Huchet6, Grégoire Rey7, Claire Morgand8, Béatrice Blondel9, Christèle Gras-Le Guen10, Matthieu Hanf8. 1. INSERM CIC1413, Nantes University Hospital, Nantes, France; INSERM UMR1153, Epidemiology and Biostatistics Sorbonne Paris Cité Centre (CRESS), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Université de Paris, Paris, France. Electronic address: sophie.de-visme@inserm.fr. 2. INSERM UMR1153, Epidemiology and Biostatistics Sorbonne Paris Cité Centre (CRESS), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Université de Paris, Paris, France; Department of General Pediatrics and Pediatric Infectious Diseases, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, Université de Paris, Paris, France. 3. Pediatric Emergency Care Unit, Nantes University Hospital, Nantes, France. 4. Pediatric Intensive Care Unit, Saint-Étienne University Hospital, Saint Etienne, France. 5. Pediatric Intensive Care Unit, Montpellier University Hospital, Montpellier, France. 6. Pediatric Intensive Care Unit, Antoine Béclère University Hospital, AP-HP, Clamart, France. 7. INSERM CépiDc, Epidemiology Center on Medical Causes of Death, Le Kremlin-Bicêtre, France. 8. INSERM UMR 1181, Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases, Versailles Saint Quentin University, Villejuif, France. 9. INSERM UMR1153, Epidemiology and Biostatistics Sorbonne Paris Cité Centre (CRESS), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Université de Paris, Paris, France. 10. INSERM CIC1413, Nantes University Hospital, Nantes, France; INSERM UMR1153, Epidemiology and Biostatistics Sorbonne Paris Cité Centre (CRESS), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Université de Paris, Paris, France; Pediatric Emergency Care Unit, Nantes University Hospital, Nantes, France.
Abstract
OBJECTIVE: To study recent epidemiologic trends of sudden unexpected death in infancy (SUDI) in Western Europe. STUDY DESIGN: Annual national statistics of death causes for 14 Western European countries from 2005 to 2015 were analyzed. SUDI cases were defined as infants younger than 1 year with the underlying cause of death classified as "sudden infant death syndrome," "unknown/unattended/unspecified cause," or "accidental threats to breathing." Poisson regression models were used to study temporal trends of SUDI rates and source of variation. RESULTS: From 2005 to 2015, SUDI accounted for 15 617 deaths, for an SUDI rate of 34.9 per 100 000 live births. SUDI was the second most common cause of death after the neonatal period (22.2%) except in Belgium, Finland, France, and the UK, where it ranked first. The overall SUDI rate significantly decreased from 40.2 to 29.9 per 100 000, with a significant rate reduction experienced for 6 countries, no significant evolution for 7 countries, and a significant increase for Denmark. The sudden infant death syndrome/SUDI ratio was 56.7%, with a significant decrease from 64.9% to 49.7% during the study period, and ranged from 6.1% in Portugal to 97.8% in Ireland. We observed between-country variations in SUDI and sudden infant death syndrome sex ratios. CONCLUSIONS: In studied countries, SUDI decreased during the study period but remained a major cause of infant deaths, with marked between-country variations in rates, trends, and components. Standardization is needed to allow for comparing data to improve the implementation of risk-reduction strategies.
OBJECTIVE: To study recent epidemiologic trends of sudden unexpected death in infancy (SUDI) in Western Europe. STUDY DESIGN: Annual national statistics of death causes for 14 Western European countries from 2005 to 2015 were analyzed. SUDI cases were defined as infants younger than 1 year with the underlying cause of death classified as "sudden infant death syndrome," "unknown/unattended/unspecified cause," or "accidental threats to breathing." Poisson regression models were used to study temporal trends of SUDI rates and source of variation. RESULTS: From 2005 to 2015, SUDI accounted for 15 617 deaths, for an SUDI rate of 34.9 per 100 000 live births. SUDI was the second most common cause of death after the neonatal period (22.2%) except in Belgium, Finland, France, and the UK, where it ranked first. The overall SUDI rate significantly decreased from 40.2 to 29.9 per 100 000, with a significant rate reduction experienced for 6 countries, no significant evolution for 7 countries, and a significant increase for Denmark. The sudden infant death syndrome/SUDI ratio was 56.7%, with a significant decrease from 64.9% to 49.7% during the study period, and ranged from 6.1% in Portugal to 97.8% in Ireland. We observed between-country variations in SUDI and sudden infant death syndrome sex ratios. CONCLUSIONS: In studied countries, SUDI decreased during the study period but remained a major cause of infant deaths, with marked between-country variations in rates, trends, and components. Standardization is needed to allow for comparing data to improve the implementation of risk-reduction strategies.
Authors: Nhung T H Trinh; Sophie de Visme; Jérémie F Cohen; Tim Bruckner; Nathalie Lelong; Pauline Adnot; Jean-Christophe Rozé; Béatrice Blondel; François Goffinet; Grégoire Rey; Pierre-Yves Ancel; Jennifer Zeitlin; Martin Chalumeau Journal: Lancet Reg Health Eur Date: 2022-03-01