Elena Philippou1,2, Sara Danuta Petersson1, Carrie Rodomar3, Elena Nikiphorou4. 1. Department of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus. 2. Diabetes and Nutritional Sciences Division, King's College London, London, UK. 3. University of Nicosia Medical School, University of Nicosia, Nicosia, Cyprus. 4. Department of Inflammation Biology, School of Immunology and Microbial Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Abstract
CONTEXT: The impact of various dietary interventions on rheumatoid arthritis (RA), characterized by immune-inflammatory response, has been subject to increased attention. OBJECTIVE: A systematic review was conducted to update the current knowledge on the effects of nutritional, dietary supplement, and fasting interventions on RA outcomes. DATA SOURCES: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, with prespecification of all methods, Medline and Embase were systematically searched for relevant articles. DATA EXTRACTION: Data were extracted by 2 independent reviewers. RESULTS: A total of 70 human studies were identified. Administration of omega-3 polyunsaturated fatty acids at high doses resulted in a reduction in RA disease activity and a lower failure rate of pharmacotherapy. Vitamin D supplementation and dietary sodium restriction were beneficial on some RA outcomes. Fasting resulted in significant but transient subjective improvements. While the Mediterranean diet demonstrated improvements in some RA disease activity measures, outcomes from vegetarian, elimination, peptide, or elemental diets suggested that responses are very individualized. CONCLUSION: Some dietary approaches may improve RA symptoms and thus it is recommended that nutrition should be routinely addressed.
CONTEXT: The impact of various dietary interventions on rheumatoid arthritis (RA), characterized by immune-inflammatory response, has been subject to increased attention. OBJECTIVE: A systematic review was conducted to update the current knowledge on the effects of nutritional, dietary supplement, and fasting interventions on RA outcomes. DATA SOURCES: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, with prespecification of all methods, Medline and Embase were systematically searched for relevant articles. DATA EXTRACTION: Data were extracted by 2 independent reviewers. RESULTS: A total of 70 human studies were identified. Administration of omega-3 polyunsaturated fatty acids at high doses resulted in a reduction in RA disease activity and a lower failure rate of pharmacotherapy. Vitamin D supplementation and dietary sodium restriction were beneficial on some RA outcomes. Fasting resulted in significant but transient subjective improvements. While the Mediterranean diet demonstrated improvements in some RA disease activity measures, outcomes from vegetarian, elimination, peptide, or elemental diets suggested that responses are very individualized. CONCLUSION: Some dietary approaches may improve RA symptoms and thus it is recommended that nutrition should be routinely addressed.
Authors: Erik Hulander; Linnea Bärebring; Anna Turesson Wadell; Inger Gjertsson; Philip C Calder; Anna Winkvist; Helen M Lindqvist Journal: J Nutr Date: 2021-12-03 Impact factor: 4.798
Authors: Rabaa Takala; Dipak P Ramji; Robert Andrews; You Zhou; James Burston; Ernest Choy Journal: Rheumatology (Oxford) Date: 2022-03-02 Impact factor: 7.580