Literature DB >> 32584247

Trends in Intravenous Magnesium Use and Outcomes for Status Asthmaticus in Children's Hospitals from 2010 to 2017.

Vineeta Mittal1,2, Matt Hall3, James Antoon4, Jessica Gold5, Chen Kenyon6,7, Kavita Parikh8,9, Rustin Morse10, Ricardo Quinonez11,12, Ronald J Teufel13, Samir S Shah14.   

Abstract

Intravenous (IV) magnesium is used as an adjunct therapy in management of status asthmaticus with a goal of reducing intubation rate. A recent review suggests that IV magnesium use in status asthmaticus reduces admission rates. This is contrary to the observation of practicing emergency room physicians. The goal of this study was to assess trends in IV magnesium use for status asthmaticus in US children's hospitals over 8 years through a retrospective analysis of children younger than 18 years using the Pediatric Health Information System database. Outcomes were IV magnesium use, inpatient and intensive care unit admission rate, geometric mean length of stay, and 7-day all-cause readmission rate. IV magnesium use for asthma hospitalization more than doubled over 8 years (17% vs. 36%; P < .001). Yearly trends were not significantly associated with hospital or intensive care unit admission rate or 7-day all-cause readmissions, although length of stay was reduced (P < .001).

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Year:  2020        PMID: 32584247      PMCID: PMC7402601          DOI: 10.12788/jhm.3405

Source DB:  PubMed          Journal:  J Hosp Med        ISSN: 1553-5592            Impact factor:   2.960


  8 in total

Review 1.  A meta-analysis on intravenous magnesium sulphate for treating acute asthma.

Authors:  D K L Cheuk; T C H Chau; S L Lee
Journal:  Arch Dis Child       Date:  2005-01       Impact factor: 3.791

Review 2.  Intravenous and nebulized magnesium sulfate for treating acute asthma in adults and children: a systematic review and meta-analysis.

Authors:  Zhilei Shan; Ying Rong; Wei Yang; Di Wang; Ping Yao; Jungang Xie; Liegang Liu
Journal:  Respir Med       Date:  2013-01-03       Impact factor: 3.415

3.  North American practice patterns of intravenous magnesium therapy in severe acute asthma in children.

Authors:  Suzanne Schuh; Charles Macias; Stephen B Freedman; Amy C Plint; Joseph J Zorc; Lalit Bajaj; Karen J Black; David W Johnson; Kathy Boutis
Journal:  Acad Emerg Med       Date:  2010-11       Impact factor: 3.451

4.  Clinical pharmacokinetics of magnesium sulfate in the treatment of children with severe acute asthma.

Authors:  Joseph E Rower; Xiaoxi Liu; Tian Yu; Michael Mundorff; Catherine M T Sherwin; Michael D Johnson
Journal:  Eur J Clin Pharmacol       Date:  2016-12-02       Impact factor: 2.953

5.  The effectiveness of magnesium sulfate for status asthmaticus outside the intensive care setting.

Authors:  Ryan L DeSanti; Nisha Agasthya; Krystal Hunter; Mohammed J Hussain
Journal:  Pediatr Pulmonol       Date:  2018-04-16

Review 6.  Intravenous magnesium sulfate for treating children with acute asthma in the emergency department.

Authors:  Benedict Griffiths; Kayleigh M Kew
Journal:  Cochrane Database Syst Rev       Date:  2016-04-29

7.  Discharging Asthma Patients on 3-Hour β-Agonist Treatments: A Quality Improvement Project.

Authors:  Huay-Ying Lo; Amanda Messer; Jennifer Loveless; Esther Sampayo; Robert H Moore; Elizabeth A Camp; Charles G Macias; Ricardo Quinonez
Journal:  Hosp Pediatr       Date:  2018-11-01

8.  Improving Inpatient Asthma Management: The Implementation and Evaluation of a Pediatric Asthma Clinical Pathway.

Authors:  Teresa G Magruder; Sridaran Narayanan; Susan Walley; Tony Powers; Hollace Whitlock; Kathleen Harrington; Terry C Wall
Journal:  Pediatr Qual Saf       Date:  2017-08-22
  8 in total
  5 in total

1.  Prospective Observational Study of Clinical Outcomes After Intravenous Magnesium for Moderate and Severe Acute Asthma Exacerbations in Children.

Authors:  Donald H Arnold; Wu Gong; James W Antoon; Leonard B Bacharier; Thomas G Stewart; David P Johnson; Wendell S Akers; Tina V Hartert
Journal:  J Allergy Clin Immunol Pract       Date:  2021-12-13

Review 2.  Stating the obvious: intravenous magnesium sulphate should be the first parenteral bronchodilator in paediatric asthma exacerbations unresponsive to first-line therapy.

Authors:  Gokul Erumbala; Sabu Anzar; Amjad Tonbari; Ramadan Salem; Colin Powell
Journal:  Breathe (Sheff)       Date:  2021-12

3.  A Novel U-Shaped Association Between Serum Magnesium on Admission and 28-Day In-hospital All-Cause Mortality in the Pediatric Intensive Care Unit.

Authors:  Chao Yan Yue; Chun Yi Zhang; Zhen Ling Huang; Chun Mei Ying
Journal:  Front Nutr       Date:  2022-02-21

4.  Intravenous Magnesium and Hospital Outcomes in Children Hospitalized With Asthma.

Authors:  James W Antoon; Matt Hall; Vineeta Mittal; Kavita Parikh; Rustin B Morse; Ronald J Teufel; Alexander H Hogan; Samir S Shah; Chén C Kenyon
Journal:  Hosp Pediatr       Date:  2021-07-01

5.  Association Between Intravenous Magnesium Therapy in the Emergency Department and Subsequent Hospitalization Among Pediatric Patients With Refractory Acute Asthma: Secondary Analysis of a Randomized Clinical Trial.

Authors:  Suzanne Schuh; Stephen B Freedman; Roger Zemek; Amy C Plint; David W Johnson; Francine Ducharme; Jocelyn Gravel; Graham Thompson; Sarah Curtis; Derek Stephens; Allan L Coates; Karen J Black; Darcy Beer; Judy Sweeney; Maggie Rumantir; Yaron Finkelstein
Journal:  JAMA Netw Open       Date:  2021-07-01
  5 in total

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