Lingang Wu1, Yanan Hao1, Yuxiu Liu1, Haibin Song1, Qingmin Wang2. 1. State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China. wangqm@nankai.edu.cn. 2. State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China. wangqm@nankai.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, People's Republic of China.
Abstract
Herein, we report a protocol for visible-light-induced dearomative oxamination reactions of indole derivatives to afford functionalized spirocyclic products. These step-economical reactions, which involve C-N and C-O bond formation, feature mild conditions, a broad substrate scope, high yields, exclusive diastereoselectivity and step-economy. In addition, a similar protocol could be used to synthesize spirolactams by dearomative amidation of phenol derivatives.
Herein, we report a protocol for visible-light-induced dearomative oxamination reactions of indole derivatives to afford functionalized n class="Chemical">spirocyclic products. These step-economical reactions, which involve C-N and C-O bond formation, feature mild conditions, a broad substrate scope, high yields, exclusive diastereoselectivity and step-economy. In addition, a similar protocol could be used to synthesize spirolactams by dearomative amidation of phenol derivatives.