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Literature DB >> 32583817

Disassembly of polymeric nanoparticles with enzyme-triggered polymer unzipping: polyelectrolyte complexes vs. amphiphilic nanoassemblies.

Vikash Kumar¹, Oyuntuya Munkhbat¹, Hatice Secinti¹, S Thayumanavan².

Abstract

Alkaline phosphatase (ALP) responsive polymers, which can unzip from head to tail are reported. Hydrophilic and hydrophobic modification of the polymer was carried out for the formation of a polyelectrolyte complex and an amphiphilic nanoassembly, respectively, which offered distinct enzyme-triggered disassembly kinetics.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2020 PMID： 32583817 PMCID： PMC7390689 DOI： 10.1039/d0cc03257c

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

20 in total

1. Programmable microcapsules from self-immolative polymers.

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Journal: J Am Chem Soc Date: 2010-08-04 Impact factor: 15.419

2. Enzyme-Responsive Polymeric Vesicles for Bacterial-Strain-Selective Delivery of Antimicrobial Agents.

Authors: Yamin Li; Guhuan Liu; Xiaorui Wang; Jinming Hu; Shiyong Liu
Journal: Angew Chem Int Ed Engl Date: 2015-12-22 Impact factor: 15.336

3. Design of polymeric carriers for cancer-specific gene targeting: utilization of abnormal protein kinase Calpha activation in cancer cells.

Authors: Jeong-Hun Kang; Daisuke Asai; Jong-Hwan Kim; Takeshi Mori; Riki Toita; Tetsuro Tomiyama; Yoji Asami; Jun Oishi; Yuko T Sato; Takuro Niidome; Byungdug Jun; Hideki Nakashima; Yoshiki Katayama
Journal: J Am Chem Soc Date: 2008-10-18 Impact factor: 15.419

Review 2. Using High Molecular Precision to Study Enzymatically Induced Disassembly of Polymeric Nanocarriers: Direct Enzymatic Activation or Equilibrium-Based Degradation?

Authors: Gadi Slor; Roey J Amir
Journal: Macromolecules Date: 2021-01-26 Impact factor: 5.985

3. Judging Enzyme-Responsive Micelles by Their Covers: Direct Comparison of Dendritic Amphiphiles with Different Hydrophilic Blocks.

Authors: Gadi Slor; Alis R Olea; Sílvia Pujals; Ali Tigrine; Victor R De La Rosa; Richard Hoogenboom; Lorenzo Albertazzi; Roey J Amir
Journal: Biomacromolecules Date: 2021-01-29 Impact factor: 6.978

4. Self-immolative Amphiphilic Diblock Copolymers with Individually Triggerable Blocks.

Authors: Xiaoli Liang; Elizabeth R Gillies
Journal: ACS Polym Au Date: 2022-06-09

4 in total

Disassembly of polymeric nanoparticles with enzyme-triggered polymer unzipping: polyelectrolyte complexes vs. amphiphilic nanoassemblies.

1. Programmable microcapsules from self-immolative polymers.

2. Enzyme-Responsive Polymeric Vesicles for Bacterial-Strain-Selective Delivery of Antimicrobial Agents.

3. Design of polymeric carriers for cancer-specific gene targeting: utilization of abnormal protein kinase Calpha activation in cancer cells.

4. Self-immolative polymers.

5. Enzyme-responsive amphiphilic PEG-dendron hybrids and their assembly into smart micellar nanocarriers.

6. Enzyme-responsive polymer assemblies constructed through covalent synthesis and supramolecular strategy.

7. UV and near-IR triggered release from polymeric nanoparticles.

8. Delineation of prognostic biomarkers in prostate cancer.

9. A matrix metalloproteinase expressed on the surface of invasive tumour cells.

10. Enzymatic Assemblies Disrupt the Membrane and Target Endoplasmic Reticulum for Selective Cancer Cell Death.

1. Multichannel dual protein sensing using amphiphilic supramolecular assemblies.

Review 2. Using High Molecular Precision to Study Enzymatically Induced Disassembly of Polymeric Nanocarriers: Direct Enzymatic Activation or Equilibrium-Based Degradation?

3. Judging Enzyme-Responsive Micelles by Their Covers: Direct Comparison of Dendritic Amphiphiles with Different Hydrophilic Blocks.

4. Self-immolative Amphiphilic Diblock Copolymers with Individually Triggerable Blocks.