Literature DB >> 32583552

Stimuli-Responsive Cycloaurated "OFF-ON" Switchable Anion Transporters.

Mohamed Fares1,2, Xin Wu1, Deepthi Ramesh3, William Lewis1, Paul A Keller2, Ethan N W Howe1,4, Ricardo Pérez-Tomás3, Philip A Gale1.   

Abstract

Anion transporters have shown potential application as anti-cancer agents that function by disrupting homeostasis and triggering cell death. In this research article we report switchable anion transport by gold complexes of anion transporters that are "switched on" in situ in the presence of the reducing agent GSH by decomplexation of gold. GSH is found in higher concentrations in tumors than in healthy tissue and hence this approach offers a strategy to target these systems to tumors.
© 2020 Wiley-VCH GmbH.

Entities:  

Keywords:  anion transport; gold complexes; molecular switch; reduction kinetics; supramolecular chemistry

Year:  2020        PMID： 32583552     DOI： 10.1002/anie.202006392

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  6 in total

1.  Controlling transmembrane ion transport via photo-regulated carrier mobility.

Authors:  Laura E Bickerton; Matthew J Langton
Journal:  Chem Sci       Date:  2022-07-08       Impact factor: 9.969

2.  Photomodulation of Transmembrane Transport and Potential by Stiff-Stilbene Based Bis(thio)ureas.

Authors:  Sander J Wezenberg; Li-Jun Chen; Jasper E Bos; Ben L Feringa; Ethan N W Howe; Xin Wu; Maxime A Siegler; Philip A Gale
Journal:  J Am Chem Soc       Date:  2021-12-21       Impact factor: 15.419

3.  Dynamic Covalent Self-Assembly of Chloride- and Ion-Pair-Templated Cryptates.

Authors:  Selina Hollstein; Oleksandr Shyshov; Marko Hanževački; Jie Zhao; Tamara Rudolf; Christof M Jäger; Max von Delius
Journal:  Angew Chem Int Ed Engl       Date:  2022-05-12       Impact factor: 16.823

4.  Organoplatinum Compounds as Anion-Tuneable Uphill Hydroxide Transporters.

Authors:  Li-Jun Chen; Xin Wu; Alexander M Gilchrist; Philip A Gale
Journal:  Angew Chem Int Ed Engl       Date:  2022-03-11       Impact factor: 16.823

5.  Redox-controlled chalcogen and pnictogen bonding: the case of a sulfonium/stibonium dication as a preanionophore for chloride anion transport.

Authors:  Gyeongjin Park; François P Gabbaï
Journal:  Chem Sci       Date:  2020-09-10       Impact factor: 9.825

Review 6.  Recent Advances in Bioactive Artificial Ionophores.

Authors:  Arundhati Roy; Pinaki Talukdar
Journal:  Chembiochem       Date:  2021-06-23       Impact factor: 3.164
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.