Literature DB >> 3258332

Mechanisms regulating the level of IL-2 mRNA in T lymphocytes.

J Shaw1, K Meerovitch, R C Bleackley, V Paetkau.   

Abstract

IL-2 mRNA has a t1/2 of 1 to 2 h in T lymphocyte cell lines and in activated human PBL. Human Jurkat cells show a rapid increase of IL-2 mRNA on induction of IL-2 synthesis, followed by an equally rapid decline 4 to 6 h later. The decline occurs despite a high rate of synthesis, and appears to be due to an enhanced rate of IL-2 mRNA degradation. The degradation of IL-2 mRNA is selectively sensitive to cycloheximide and actinomycin D, inhibitors of protein and RNA synthesis, respectively. IL-2 mRNA levels in mouse EL4.E1 T lymphoma cells, and in activated human PBL, decline rapidly on removal of the inducing agents, indicating that transcription continues only as long as the activating signal is present. The transience of IL-2 mRNA is seen as an important property of a transiently acting immunoregulatory factor.

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Year:  1988        PMID： 3258332

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  26 in total

1.  Global mRNA stabilization preferentially linked to translational repression during the endoplasmic reticulum stress response.

Authors:  Tomoko Kawai; Jinshui Fan; Krystyna Mazan-Mamczarz; Myriam Gorospe
Journal:  Mol Cell Biol       Date:  2004-08       Impact factor: 4.272

2.  The 2-kilobase intron of the herpes simplex virus type 1 latency-associated transcript has a half-life of approximately 24 hours in SY5Y and COS-1 cells.

Authors:  Darby L Thomas; Martin Lock; Janice M Zabolotny; Bangalore R Mohan; Nigel W Fraser
Journal:  J Virol       Date:  2002-01       Impact factor: 5.103

3.  Inhibition of interleukin-2 gene expression by human herpesvirus 6B U54 tegument protein.

Authors:  Mathieu Iampietro; Guillaume Morissette; Annie Gravel; Louis Flamand
Journal:  J Virol       Date:  2014-08-13       Impact factor: 5.103

4.  A binding factor for interleukin 2 mRNA.

Authors:  J Hua; V Paetkau
Journal:  Nucleic Acids Res       Date:  1996-03-01       Impact factor: 16.971

5.  Armed CD4+ Th1 effector cells and activated macrophages participate in bile duct injury in murine biliary atresia.

Authors:  Cara L Mack; Rebecca M Tucker; Ronald J Sokol; Brian L Kotzin
Journal:  Clin Immunol       Date:  2005-05       Impact factor: 3.969

6.  Activation markers and cell proliferation as indicators of toxicity: a flow cytometric approach.

Authors:  A Johannisson; A Thuvander; I L Gadhasson
Journal:  Cell Biol Toxicol       Date:  1995-12       Impact factor: 6.691

7.  AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A).

Authors:  C A Lagnado; C Y Brown; G J Goodall
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

8.  Trypanosoma cruzi immunosuppressive factor decreases the interleukin-2 mRNA level in cultured normal activated human lymphocytes.

Authors:  S Majumder; F Kierszenbaum
Journal:  Infect Immun       Date:  1995-11       Impact factor: 3.441

9.  Altered gene transcription after burn injury results in depressed T-lymphocyte activation.

Authors:  A F Horgan; M V Mendez; D S O'Riordain; R G Holzheimer; J A Mannick; M L Rodrick
Journal:  Ann Surg       Date:  1994-09       Impact factor: 12.969

10.  Role of CD4 molecule in the induction of interleukin 2 and interleukin 2 receptor in class II major histocompatibility complex-restricted antigen-specific T helper clones. T cell receptor/CD3 complex transmits CD4-dependent and CD4-independent signals.

Authors:  N Oyaizu; N Chirmule; S Pahwa
Journal:  J Clin Invest       Date:  1992-06       Impact factor: 14.808
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