Pu Jia1, RuiDeng Wang2, Jing Yuan3, Hao Chen2, Li Bao2, Fei Feng2, Hai Tang2. 1. Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong'an Road, Xicheng District, Beijing, China. Jiapu@ccmu.edu.cn. 2. Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong'an Road, Xicheng District, Beijing, China. 3. Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang, Dongcheng District, Beijing, China.
Abstract
INTRODUCTION: The pregnancy and lactation-associated osteoporosis (PLO) is a rare disease whose precise pathophysiological mechanisms remain mostly unknown. CASE REPORT: We reported here a case of PLO that occurred in the early postpartum period and led to multiple compression fractures. Combination therapy with alendronate, calcium carbonate, and vitamin D was used to treat the patient and a marked but gradual increase in the density of bone mineral was observed. Moreover, no further fractures have occurred. CONCLUSION: PLO is a very rare type of osteoporosis associated with severe chronic back pain. Increased bone resorption significantly increases the risk of bone fractures in women with PLO. Early diagnosis, stopping breastfeeding, treatment of calcium and vitamin D, bisphosphonates, or other antiosteoporosis medicine and regular follow-ups of these cases are particularly important in the prevention of fractures and to increase the quality of life of patients.
INTRODUCTION: The pregnancy and lactation-associated osteoporosis (PLO) is a rare disease whose precise pathophysiological mechanisms remain mostly unknown. CASE REPORT: We reported here a case of PLO that occurred in the early postpartum period and led to multiple compression fractures. Combination therapy with alendronate, calcium carbonate, and vitamin D was used to treat the patient and a marked but gradual increase in the density of bone mineral was observed. Moreover, no further fractures have occurred. CONCLUSION: PLO is a very rare type of osteoporosis associated with severe chronic back pain. Increased bone resorption significantly increases the risk of bone fractures in women with PLO. Early diagnosis, stopping breastfeeding, treatment of calcium and vitamin D, bisphosphonates, or other antiosteoporosis medicine and regular follow-ups of these cases are particularly important in the prevention of fractures and to increase the quality of life of patients.
Entities:
Keywords:
Alendronate; Pathogenesis; Pregnancy and lactation-associated osteoporosis (PLO); Treatment
Authors: Abraham Yair Lujano-Negrete; Martha Cecilia Rodríguez-Ruiz; Cassandra Michele Skinner-Taylor; Lorena Perez-Barbosa; Jesus Alberto Cardenas de la Garza; Pedro Alberto García-Hernández; Luis Gerardo Espinosa-Banuelos; Luz Fernanda Gutierrez-Leal; Sofia Jezzini-Martínez; Dionicio Ángel Galarza-Delgado Journal: Arch Osteoporos Date: 2022-02-19 Impact factor: 2.617